ASSOCIATION BETWEEN VITAMIN D SUPPLEMENTATION IN EARLY PREGNANCY AND SMALL FOR GESTATIONAL AGE

LI Xiu; WANG Shan-shan; LEI Gang; YANG Xue-feng; SHEN Jian; HAO Li-ping

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (5) : 423-430.

ORIGINAL ARTICLES

LI Xiu¹, WANG Shan-shan², LEI Gang³, YANG Xue-feng², SHEN Jian³, HAO Li-ping²

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Abstract

Objective To prospectively explore the association between vitamin D (VD) supplementation in early pregnancy and the risk of small for gestational age (SGA) among pregnant women in Wuhan. Methods Participants were all from the Tongji birth cohort conducted from 2018 to 2022. Information on socio-demographic characteristics, lifestyle, and nutritional supplement consumption was collected through face-to-face surveys. SGA refers to an infant with a birth weight below the 10th percentile for the gestational age. According to the dosage and duration of VD supplementation, participants were divided into four groups: non-user group (VD=0 IU/d), low-dose group (VD-L, VD<400 IU/d for any duration), high-dose short-term group (VD-HS, VD≥400 IU/d with<2 months), and high-dose long-term group (VD-HL, VD≥400 IU/d with≥2 months). Multiple logistic regressions were used to evaluate the correlation between VD supplementation and SGA risk. Results A total of 2558 subjects were included. The average age was 28.89±3.49 years. Compared with the Non-users, pregnant women in the VD-HL group had higher education levels, per capita monthly household income, and the proportion of sunscreen use, and were more likely to be primiparous women (P<0.05). The multivariate logistic regression model showed that compared to the non-users, women in VD-HL group was associated with a 50% reduction in the risk of SGA (OR=0.50, 95% CI: 0.33, 0.75). No significant association was found between VD-L, VD-HS groups and the risk of SGA. Conclusion High-dose and long-term VD supplementation in early pregnancy reduces the risk of SGA.

Key words

vitamin D / vitamin D supplementation / small for gestational age / early pregnancy

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LI Xiu, WANG Shan-shan, LEI Gang, YANG Xue-feng, SHEN Jian, HAO Li-ping. ASSOCIATION BETWEEN VITAMIN D SUPPLEMENTATION IN EARLY PREGNANCY AND SMALL FOR GESTATIONAL AGE[J]. Acta Nutrimenta Sinica. 2024, 46(5): 423-430

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