EFFECTS OF BIFIDOBACTERIUMb ANIMALIS SUBSP. LACTIS TY-S01 ON BODY COMPOSITION, INFLAMMATORY FACTORS, AND GUT MICROBIOTA IN SIMPLE OBESE INDIVIDUALS

NIU Xiao-kang; ZHANG Qi; ZHANG Feng; WANG Ran; WANG Jing; HE Jing-jing

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (5) : 447-456.

NIU Xiao-kang¹, ZHANG Qi¹, ZHANG Feng², WANG Ran¹, WANG Jing², HE Jing-jing¹

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Abstract

Objective To study the effects of Bifidobacterium simple obese adults animalis subsp. lactis TY-S01 (TY-S01) on body composition, inflammatory factors and gut microbiota in simple obese adults. Methods Thirty adults with simple obesity were recruited and randomly divided into two groups, including 15 in the test group (TY-S01 group), who consumed the TY-S01 solid drink (live bacteria content of 5×10¹⁰ CFU), and 15 in the control group, who consumed the placebo (maltodextrin) for 12 weeks. Dietary information was recorded and body composition was measured before and after intervention. Blood and stool samples were collected and tested for blood lipids, inflammatory factors, hepatic and renal function parameters and gut microbiota. Results After intervention, body fat percentage and visceral fat area decreased in the TY-S01 group. The decrease in body fat percentage, visceral fat area, serum total cholesterol and low-density lipoprotein cholesterol were significantly greater in the TY-S01 group than in the placebo group. Serum tumor necrosis factor α levels decreased significantly in the TY-S01 group. After intervention, the feces from the placebo group were significantly enriched in obesity-related harmful genera such as g__Anaerostipes, g__unclassified_f__Lachnospiraceae, and g__Coprococcus, while those from the TY-S01 group were significantly enriched in beneficial genera such as o__Pseudomonadales and g__Peptoniphilus. Correlation analysis revealed that g__Anaerostipes was significantly and positively correlated with increased body lipids, and g__unclassified_f__Lachnospiraceae was significantly and positively correlated with increased body fat, blood lipids, and inflammatory factors. Conclusion Our findings indicate that TY-S01 is effective in reducing body fat, blood lipids and inflammation levels in simple obese individuals possibly via the decreasing the abundances of g__Anaerostipes and g__unclassified_f__Lachnospiraceae and the increasing the abundances of o__Pseudomonadales and g__Peptoniphilus.

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Bifidobacterium animalis subsp. lactis TY-S01 / obesity / inflammation / intestinal microbiome

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NIU Xiao-kang, ZHANG Qi, ZHANG Feng, WANG Ran, WANG Jing, HE Jing-jing. EFFECTS OF BIFIDOBACTERIUMb ANIMALIS SUBSP. LACTIS TY-S01 ON BODY COMPOSITION, INFLAMMATORY FACTORS, AND GUT MICROBIOTA IN SIMPLE OBESE INDIVIDUALS[J]. Acta Nutrimenta Sinica. 2024, 46(5): 447-456

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