THE ROLE OF SHORT-CHAIN FATTY ACIDS IN THE ACTION OF THE MICROBIAL-GUT-BRAIN AXIS ON THE DEVELOPMENT OF NEUROPSYCHIATRIC DISORDERS

CHEN Lu; TAO Fang-biao; HUANG Kun

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (5) : 512-518.

CHEN Lu¹, TAO Fang-biao¹, HUANG Kun^1,2

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Abstract

The intestinal microbiota plays an important role in the signaling process of the gut-brain axis, but the mechanism of microbiota-gut-brain (MGB) intercommunication is still unclear. Short-chain fatty acids (SCFAs) may play an important role in MGB communication as a key candidate mediator. However, the potential mechanisms by which SCFAs affect brain physiology and behaviors have not been fully elucidated, and there are few reports on the relationship between SCFAs and MGB in China. We outline the metabolic and physiological actions of SCFAs, evidences for their association with the occurrence of major neuropsychiatric disorders, and their possible pathways of action on the gut-brain signaling pathway. The transgenerational effects of SCFAs on offspring brain development are also discussed.

Key words

short-chain fatty acids / gut microbes / microbial-gut-brain axis / brain function

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CHEN Lu, TAO Fang-biao, HUANG Kun. THE ROLE OF SHORT-CHAIN FATTY ACIDS IN THE ACTION OF THE MICROBIAL-GUT-BRAIN AXIS ON THE DEVELOPMENT OF NEUROPSYCHIATRIC DISORDERS[J]. Acta Nutrimenta Sinica. 2024, 46(5): 512-518

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