Objective To analyze the effects of dietary folate and related vitamins intake during pregnancy on neonates folate metabolism levels. Methods Pregnant women（23 to 29 weeks of gestation）were recruited from maternal and child health care hospital of Beijing and Shandong from the "Mother&Child Nutrition and Health Cohort". A dietary survey was conducted using a 3-day 24-hour dietary recall to calculate the intakes of the dietary folate, vitamin B6 and vitamin B12. After follow-up to delivery, neonatal cord blood was collected and the levels of red blood cell folate, serum folate, and total homocysteine were detected. Results A total of 139 pairs of pregnant women and neonates were included in the study. The median values of neonatal umbilical cord blood erythrocyte folate, serum folate and homocysteine were 925.86 (P25-P75: 854.77-1040.09) ng/ml, 49.60 (P25-P75: 37.57-53.48) nmol/L and 5.32 (P25-P75: 3.67-6.47) μ mol/L, respectively. The maternal dietary folate intake was insufficient, and neonatal umbilical cord blood erythrocyte folate and serum folate levels were lower, while the tHcy levels were higher. However, there is no significant difference (P>0.05). The neonatal umbilical cord blood tHcy level was higher in mother with insufficient dietary vitamin B6 intake, but there was no significant difference [P50 (P25-P 75): 5.38 (3.74-6.62) vs 4.23 (2.75-6.15), P=0.063]. Multiple linear regression analysis showed that the levels of folate in umbilical cord blood erythrocytes, serum folic acid and tHcy were not significantly correlated with the intake of dietary related vitamins during pregnancy (P>0.05). Conclusion The intakes of dietary folate and related vitamins during pregnancy were not significantly correlated with folic acid metabolism levels in neonatal umbilical cord blood, which needs further study.
Key words
pregnancy /
diet /
folate /
newborn umbilical cord blood /
homocysteine
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Greene ND, Copp AJ.Neural tube defects[J].Annu Rev Neurosci,2014,37:221–242.
[2] Visentin CE, Masih SP, Plumptre L, et al. Low serum vitamin B12 concentrations are prevalent in a corhort of pregnant Canadian women[J]. J Nutr,2016,146:1035–1042.
[3] Plumptre L,Masih SP,Ly A,et al. High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood[J].Am J Clin Nutr,2015,102:848–857.
[4] Seok AH.Relation between folate levels of maternal-unbilical cord blood,placenta tissue and pregnancy outcomes[J].J Comm Nutr,2004,6:91–96.
[5] Du YJ, Li J, Qu PF, et al. Nonlinear relationship between maternal and cord blood vitamin B12 and folate from a Chinese population-based study[J].Int J Women Health,2023,15:1405–1415.
[6] 孙京,鹿璐,胡蕊,等.孕期叶酸营养状况对新生儿脐带血叶酸水平的影响[J].中国食物与营养,2022,28:74–78,84.
[7] 中国营养学会.中国居民膳食营养素参考摄入量 2013版 [M].北京:科学出版社,2014:402.
[8] Li Q,Xu S,Chen X,et al. Folic acid supplement use and increased risk of gestational hypertension[J]. Hyper-tension,2020,76:150–156.
[9] Schulze KJ, Gernand AD, Khan AZ, et al. Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplentation in rural Bangladesh[J].Am J Clin Nutr,2020,112:1328–1337.
[10] Antony AC.In utero physiology: role of folic acid in nutrient delivery and fetal development[J].Am J Clin Nutr, 2007,85:598S–603S.
[11] Henderson GI, Perez T, Schenker S, et al. Maternal-to-fetal transfer of 5-methyltetrahydrofolate by the perfused human placental cotyledon: evidence for a concentrative role by placental folate receptors in fetal folate delivery[J]. Lab Clin Med,1995,126:184–203.
[12] 董振. 围孕期叶酸补充与妊娠期糖尿病发病风险及妊娠结局相关性研究[D].合肥:安徽医科大学,2022.
[13] Radziejewska A,Chmurzynska A.Erratum to folate and choline absorption and uptake: their role in fetal development[J].Biochimie,2019,160:129.
[14] Melse-Boonstra A, Hlom PI, Ueland PM, et al. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations[J].Am J Clin Nutr,2005,81:1378–1382.
[15] Holmes VA, Wallace JMW, Alexander HD, et al.Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status form continued folic acid supplementation[J].Clin Chem,2005,51:629–634.
[16] Macfarlane AJ,Greene-finestone LS,Shi Y.Vitamin B12and homocysteine status in a folate-replete population:results from the Canadian Health Measures Survey[J].Am J Clin Nutr,2011,94:1079–1087.
