RESEARCH PROGRESS ON THE RELATIONSHIP BETWEEN &#x003c9;-3 POLYUNSATURATED FATTY ACIDS AND DEPRESSIVE DISORDER

ZHOU Jue; LIANG Yan-zi; ZHANG Xin-wen; ZHONG Hao; LI Yun-hong

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (6) : 612-617.

CRITICAL REVIEWS

RESEARCH PROGRESS ON THE RELATIONSHIP BETWEEN ω-3 POLYUNSATURATED FATTY ACIDS AND DEPRESSIVE DISORDER

ZHOU Jue¹, LIANG Yan-zi^2,3, ZHANG Xin-wen², ZHONG Hao³, LI Yun-hong^2,3

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Abstract

Depressive disorder, a common mood disorder or affective disorder, has become a major cause of disability, affecting the health status of hundreds of millions of people worldwide. ω-3 Polyunsaturated fatty acids (ω-3 PUFAs) are critical for the development and function of the central nervous system. Previous studies found that ω-3 PUFAs were associated with depression and might be a therapeutical intervention for depression. We mainly outline research progress on anti-depression effects of ω-3 PUFAs, and analyze the possible anti-depression mechanism of ω-3 PUFAs. The specific mechanism of ω-3 PUFAs action on the depressive disorder, especially the gut microbiota-gut-brain axis may be the future research direction.

Key words

ω-3 PUFAs / depressive disorder / mechanism

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ZHOU Jue, LIANG Yan-zi, ZHANG Xin-wen, ZHONG Hao, LI Yun-hong. RESEARCH PROGRESS ON THE RELATIONSHIP BETWEEN ω-3 POLYUNSATURATED FATTY ACIDS AND DEPRESSIVE DISORDER[J]. Acta Nutrimenta Sinica. 2024, 46(6): 612-617

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