Objective To design and develop a national nutrition and health assessment system. Methods By integrating the “Internet +” and cloud platform technology, smart mobile terminal of mobile phones and PAD, mini APP, auxiliary measurement and wearable devices, the national nutrition and health assessment system was developed. Results This system includes a management platform, a professional version of a dietary survey APP, a dietary assistance survey mini program, and a home nutrition and health monitoring APP. The management platform includes system management, project management, questionnaire management, dietary survey, physical examination, laboratory examination, physical activity survey, electronic questionnaire survey, data quality control, statistical analysis, individual evaluation, educational management and so on. The surveyed subjects can record their dietary information in real-time through a dietary assistance survey mini program, and the dietary information will be synchronized to the professional version of the dietary survey APP automatically to reduce recall errors. Data such as blood pressure, blood sugar and exercise are automatically transmitted through sphygmomanometer, blood glucose meter and kitchen scale, etc. Conclusion This system provides a tool for high-quality and refined implementation of nutritional health surveys, which can reduce dietary survey time, decrease recall errors, provide image references for professional investigators to estimate food weight, and improve survey efficiency and effectiveness.