CONTENTS OF VITAMIN A IN MATERNAL PLASMA, UMBILICAL CORD PLASMA AND HUMAN MILK IN THREE CITIES OF NORTHERN CHINA

YIN Huan-huan; TIAN Luo-jia; ZHAO Yan-rong; LI Xiang; MAO Ying-yi; CHEN Jin-yao

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Acta Nutrimenta Sinica ›› 2025, Vol. 47 ›› Issue (2) : 119-124.

ORIGINAL ARTICLES

CONTENTS OF VITAMIN A IN MATERNAL PLASMA, UMBILICAL CORD PLASMA AND HUMAN MILK IN THREE CITIES OF NORTHERN CHINA

YIN Huan-huan¹, TIAN Luo-jia¹, ZHAO Yan-rong², LI Xiang², MAO Ying-yi², CHEN Jin-yao¹

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Abstract

Objective To investigate the contents of vitamin A (VA) in maternal plasma, umbilical cord plasma and human milk at different lactation stages in three cities of northern China, analyze the changing trend of VA content in human milk, and explore the association between maternal plasma and umbilical cord plasma as well as human milk. Methods Healthy full-term pregnant women were recruited in three northern cities including Tianjin, Changchun and Lanzhou. Their venous plasma (i.e., maternal plasma), umbilical cord plasma during delivery, and colostrum, transitional as well as mature milk samples during lactation were collected. The contents of VA in samples were analyzed by high-performance liquid chromatography. Results The contents of VA [median (P25, P75)] in maternal plasma and umbilical cord plasma at delivery in the three cities were 310.45 (243.19, 389.60) μg/L, 151.30 (128.49, 175.09) μg/L, respectively. The contents of VA in colostrum, transitional milk and mature milk were 695.97 (509.92, 854.90) μg/L, 224.27 (155.17, 300.10) μg/L, 100.75 (63.50, 162.00) μg/L, respectively. The contents of VA in breast milk decreased gradually with the extension of the lactation period (P<0.05). The prevalence of vitamin A deficiency (VAD) was 15.12%. In pregnant women with VAD, a positive association was found between the contents of VA in human colostrum milk and maternal plasma (r=0.676, P=0.011). Conclusion The contents of VA in human milk decrease gradually with the prolongation of the lactation period. When the content of maternal VA is at a low level, the content of VA in human colostrum milk decreases with the decrease of VA in maternal plasma. The findings in this study address the significance of VAD status in northern China.

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vitamin A / maternal plasma / umbilical cord plasma / human milk / northern China

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YIN Huan-huan, TIAN Luo-jia, ZHAO Yan-rong, LI Xiang, MAO Ying-yi, CHEN Jin-yao. CONTENTS OF VITAMIN A IN MATERNAL PLASMA, UMBILICAL CORD PLASMA AND HUMAN MILK IN THREE CITIES OF NORTHERN CHINA[J]. Acta Nutrimenta Sinica. 2025, 47(2): 119-124

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