ASSOCIATION BETWEEN SERUM FERRITIN LEVEL AND GLUCOSE METABOLISM-RELATED INDICATORS IN CHINESE ADULTS

LIU Xin-tian; ZHANG Wan-yu; WANG Xin-yue; HE Zhang-ya; LUO Xiao-qin

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Acta Nutrimenta Sinica ›› 2025, Vol. 47 ›› Issue (3) : 223-227.

ORIGINAL ARTICLES

ASSOCIATION BETWEEN SERUM FERRITIN LEVEL AND GLUCOSE METABOLISM-RELATED INDICATORS IN CHINESE ADULTS

LIU Xin-tian^1,2, ZHANG Wan-yu¹, WANG Xin-yue¹, HE Zhang-ya¹, LUO Xiao-qin^1,3

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Abstract

Objective To investigate the association of serum ferritin (SF) with glycemic parameters, including fasting glucose, fasting insulin, glycosylated hemoglobin, and insulin resistance index. Methods The subjects of the 2009 China Health and Nutrition Survey (CHNS) were stratified by sex and divided into four groups according to the quartile of SF level. Logistic regression was used to study the risk association between SF and glucose metabolism-related indexes, and the dose-response relationship was explored by restricted cubic spline. Results A total of 7271 subjects participants were included in this studyin which 3276 were males and 3995 were females and serum ferritin levels were significantly higher in males than females. In males, the highest SF level group (Q4) had a higher risk of hyperglycemia, glycated hemoglobin abnormalities, and insulin resistance compared with the lowest SF level group (Q1) (Ptrend<0.05) with a linear dose-response association (Poverall<0.05, Pnonlinear>0.05). In females, the highest SF level group (Q4) had a higher risk of hyperglycemia, insulin resistance, hyperinsulinemia, and glycated hemoglobin abnormality compared with the lower SF level group (Q2) (Ptrend<0.05). There was a nonlinear dose-response association between SF and the first three indicaters (Poverall<0.05, Pnonlinear<0.05) and a linear dose-response association with glycated hemoglobin abnormalities (Poverall<0.05, Pnonlinear>0.05). Conclusion There is a dose-response association between SF level and glycemic parameters in Chinese adult. For those with hyperglycemia, it isrecommended that SF should be maintained at a lower level within the current normal range.

Key words

serum erritin / glucose metabolism / hyperglycaemia / insulin resistance / hyperinsulinaemia

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LIU Xin-tian, ZHANG Wan-yu, WANG Xin-yue, HE Zhang-ya, LUO Xiao-qin. ASSOCIATION BETWEEN SERUM FERRITIN LEVEL AND GLUCOSE METABOLISM-RELATED INDICATORS IN CHINESE ADULTS[J]. Acta Nutrimenta Sinica. 2025, 47(3): 223-227

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