THE RELATIONSHIP BETWEEN SERUM VITAMIN D CONCENTRATION AND RISK OF DYSLIPIDEMIA IN CHILDREN AND ADOLESCENTS IN FUJIAN PROVINCE

LI Yang-fan; YANG Li-jun; HUANG Zheng; JIANG Mei-hua; WU Hui-dan; LAI Shang-rong

PDF(1003 KB)

Acta Nutrimenta Sinica ›› 2025, Vol. 47 ›› Issue (3) : 239-244.

THE RELATIONSHIP BETWEEN SERUM VITAMIN D CONCENTRATION AND RISK OF DYSLIPIDEMIA IN CHILDREN AND ADOLESCENTS IN FUJIAN PROVINCE

LI Yang-fan, YANG Li-jun, HUANG Zheng, JIANG Mei-hua, WU Hui-dan, LAI Shang-rong

Author information +

History +

Abstract

Objective To investigate the correlation between serum vitamin D (VD) levels and dyslipidemia in children and adolescents. Methods A total of 1873 children and adolescents aged 6 to 18 years were selected through multi-stage stratified random cluster sampling. Questionnaire surveys and physical examination were performed. Lipid profiles and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The association between 25(OH)D levels and dyslipidemia was analyzed using unconditional Logistic regression. Results Serum VD levels were positively correlated with TC and LDL-C concentrations and negatively correlated with TG levels (r_TC=0.167, r_TG=–0.139, r_LDL-C=0.144; All P<0.001). After adjusted for gender, age, region, sleep, moderate-to-high-intensity physical activity, daily outdoor activities, and nutrient supplement intake, logistic regression analysis indicated that those in the lowest quartile (first quartile) had a significantly lower risk of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) abnormalities compared with individuals in the highest quartile of VD levels (fourth quartile) (OR_TC=0.306;95%CI: 0.171-0.549;OR_LDL-C=0.287;95%CI: 0.151-0.545). In contrast, individuals in the third quartile of VD levels exhibited a higher risk of triglyceride (TG) abnormalities compared with individuals in the highest quartile of VD levels (fourth quartile) (OR_TG=1.764;95%CI: 1.183~2.632). Conclusion Serum VD has different effects on different lipid components. Lower VD levels are associated with a reduced risk of TC and LDL-C abnormalities but an increased risk of TG abnormalities.

Key words

vitamin D / dyslipidemia / children and adolescents

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LI Yang-fan, YANG Li-jun, HUANG Zheng, JIANG Mei-hua, WU Hui-dan, LAI Shang-rong. THE RELATIONSHIP BETWEEN SERUM VITAMIN D CONCENTRATION AND RISK OF DYSLIPIDEMIA IN CHILDREN AND ADOLESCENTS IN FUJIAN PROVINCE[J]. Acta Nutrimenta Sinica. 2025, 47(3): 239-244

References

[1] 中国血脂管理指南修订联合专家委员会. 中国血脂管理指南(2023年)[J]. 中国循环杂志,2023,38:237-271.
[2] Hajhashemy Z, Tirani SA, Askari G, et al. The association between serum vitamin D levels and abnormal lipid profile in pediatrics: a GRADE-assessed systematic review and dose-response meta-analysis of epidemiologic studies[J]. Nutr Revi, 2024: nuae020.
[3] Xiao P, Cheng H, Li H, et al. Vitamin D trajectories and cardiometabolic risk factors during childhood: a large population-based prospective cohort study[J]. Front Cardiovasc Med,2022 ,9:836376.
[4] Lee SH, Kim SM, Park HS, et al. Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children[J]. Nutr Metab Cardiovasc Dis, 2013,23:785-791.
[5] Song K, Park G, Choi Y, et al. Association of vitamin D status and physical activity with lipid profile in Korean children and adolescents: a population-based study[J]. Children (Basel),2020,7:241.
[6] Gannagé-Yared MH, Sabbagh R, Chédid R .Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children[J]. J Endocrinol Invest, 2018,41:1043-1049.
[7] Ashraf AP, Alvarez JA, Gower BA, et al. Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females[J]. Obesity (Silver Spring),2011,19:2214-221.
[8] Delvin EE, Lambert M, Levy E, et al. Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents[J]. J Nutr,2010,140: 987-991.
[9] Al-Daghri NM, Sabico S, Al-Saleh Y, et al. Calculated adiposity and lipid indices in healthy Arab children as influenced by vitamin D status[J]. J Clin Lipidol, 2016,10:775-781.
[10] Hauger H, Laursen RP, Ritz C, et al. Effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis of randomized controlled trials[J]. Eur J Nutr,2020,59:873-884.
[11] Tang Z, Huang S, Ma R, et al. Low vitamin D status is associated with obesity but no other cardiovascular risk factors in Chinese children and adolescents[J]. Nutr Metab Cardiovasc Dis, 2020,30:1573-1581.
[12] Kim YS, Hwang JH, Song MR.The association between vitamin D deficiency and metabolic syndrome in Korean adolescents[J]. J Pediatr Nurs,2018,38:e7-e11.
[13] 中华人民共和国国家卫生健康委员会.人群维生素D缺乏筛查方法:WS/T 677-2020[S]. 2020.
[14] 中华医学会儿科学分会罕见病学组,中华医学会儿科学分会心血管学组,中华医学会儿科学分会儿童保健学组,等. 儿童脂质异常血症诊治专家共识(2022)[J]. 中华儿科杂志,2022,60:633-639.
[15] 国家卫生部学校卫生标准专业委员会. 学龄儿童青少年营养不良筛查:WS/T 456-2014[S].北京:中国质检出版社,2014.
[16] 中华人民共和国国家卫生和计划生育委员会.儿童青少年超重与肥胖筛查:WS/T 586-2018[S]. 2018.
[17] 胡霄,姜红如,张兵,等. 中国十五省7~17岁儿童青少年心血管代谢性危险因素的流行特征[J]. 环境与职业医学,2021,38:833-838.
[18] 姚婉雯,梁健平,谈蔚清,等. 广州市中小学生课外体育活动与血脂异常的关联分析[J]. 中华心血管病杂志,2021,49:708-713
[19] Dathan-Stumpf A, Vogel M, Rieger K,et al. Serum lipid levels were related to socio-demographic characteristics in a German population-based child cohort[J]. Acta Paediatr, 2016,105:e360-e367.
[20] 杨彦. 6~18岁儿童青少年膳食结构及脂肪酸构成对血脂水平的影响[D]. 宁夏:宁夏医科大学,2012.
[21] 丁钢强,马爱国.中国居民膳食指南科学研究报告2021[M].北京:人民卫生出版社,2021.
[22] 张浩,董洋洋,马萍,等.中国儿童青少年维生素D营养状况的Meta分析[J].中国循证医学杂志,2021,21:284-289.
[23] Pilz, S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes[J]. Curr Diab Rep,2013,13:261–270 .
[24] Wolden-Kirk H, Overbergh L, Christesen HT,et al. Vitamin D and diabetes:its importance for beta cell and immune function[J]. Mol Cell Endocrinol,2011, 347:106–120.
[25] Jorde R, Grimnes G.Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids[J]. Prog Lipid Res,2011, 50:303-312.
[26] Wong KE, Szeto FL, Zhang W,et al. Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins[J]. Am J Physiol Endocrinol Metab,2009,296:E820-E828.
[27] Patwardhan VG, Mughal ZM, Padidela R,et al. Randomized control trial assessing impact of increased sunlight exposure versus vitamin D supplementation on lipid profile in Indian vitamin D deficient men[J]. Indian J Endocrinol Metab.,2017,21:393-398.
[28] Dace A, Martin-el Yazidi C, Bonne J,et al. Calcitriol is a positive effector of adipose differentiation in the OB 17 cell line: relationship with the adipogenic action of triiodothyronine[J]. Biochem Biophys Res Commun,1997,232:771-776.
[29] Shi H, Norman AW, Okamura WH, et al. 1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes[J]. FASEB J, 2002, 16:1808-1810.
[30] Wang Q, Miao X, Hu M,et al. Nonlinear relationship between serum 25-hydroxyvitamin D and lipid profile in Chinese adults[J]. Front Nutr, 2024,11:1388017.