ROLE OF ZINC RECEPTOR GPR39 IN DEPRESSION DEVELOPMENT

LI Chen-qi; MIAO Gen; LU Hong-tao; TANG Yu-xiao; SHEN Hui

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Acta Nutrimenta Sinica ›› 2025, Vol. 47 ›› Issue (4) : 397-400.

CRITICAL REVIEWS

ROLE OF ZINC RECEPTOR GPR39 IN DEPRESSION DEVELOPMENT

LI Chen-qi^1,2, MIAO Gen¹, LU Hong-tao¹, TANG Yu-xiao¹, SHEN Hui¹

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Abstract

Depression is one of the most common mental disorders. Zinc is the only identified endogenous ligand for G protein-coupled receptor 39 (GPR39) to date. GPR39 is widely distributed in the nervous system. Recent studies have shown a close association between zinc and its receptor GPR39 and depression. Abnormal expression and functional changes of GPR39 can affect neurotransmitter balance and neural plasticity, thereby influencing the development of depression. Agonists of GPR39 have shown certain potential application value in the prevention and treatment of depression.

Key words

G protein-coupled receptor 39 (GPR39) / zinc / depression

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LI Chen-qi, MIAO Gen, LU Hong-tao, TANG Yu-xiao, SHEN Hui. ROLE OF ZINC RECEPTOR GPR39 IN DEPRESSION DEVELOPMENT[J]. Acta Nutrimenta Sinica. 2025, 47(4): 397-400

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