ASSOCIATION BETWEEN COMPOSITE DIETARY ANTIOXIDANT INDEX AND GYNECOLOGICAL CANCERS: A CROSS-SECTIONAL ANALYSIS OF THE DATA FROM NHANES 2013&#x02013;2023

YAN Yu-qing; XU Ming-dan; YANG Liu; BO Ya-cong; LYU Quan-jun

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Acta Nutrimenta Sinica ›› 2025, Vol. 47 ›› Issue (5) : 439-445.

ASSOCIATION BETWEEN COMPOSITE DIETARY ANTIOXIDANT INDEX AND GYNECOLOGICAL CANCERS: A CROSS-SECTIONAL ANALYSIS OF THE DATA FROM NHANES 2013–2023

YAN Yu-qing¹, XU Ming-dan¹, YANG Liu¹, BO Ya-cong¹, LYU Quan-jun^1,2,*

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Abstract

Objective This cross-sectional study utilized National Health and Nutrition Examination Survey (NHANES) data to investigate the epidemiological relationship between Composite Dietary Antioxidant Index (CDAI) and female-specific malignancies, providing evidence for optimizing dietary strategies in female cancer prevention. Methods A total of 12 624 women aged ≥20 years (mean age: 51.2 years) from NHANES (2013-2023) were included. CDAI was calculated from two 24-hour dietary recalls by integrating intakes of vitamins A,C,E, zinc, selenium, and carotenoids. Spearman correlation analysis was used to initially assess linear associations between CDAI and gynecological cancers. Multivariable logistic regression models (adjusted for demographic, socioeconomic, and lifestyle confounders) were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) across the CDAI quartiles (Q1-Q4). Subgroup heterogeneity was examined. Results CDAI was significantly and inversely correlated with uterine cancer (r=–0.023, P=0.01) and cervical cancer (r=–0.25, P=0.005), but not significantly associated with breast or ovarian cancer (P>0.05). Multivariate models revealed that the risk of uterine cancer in the highest quartile group (Q4) of CDAI was significantly lower than that in the Q1 group (OR=0.488, 95%CI: 0.285-0.834, P=0.011). Subgroup analyses indicated a more pronounced negative correlation between CDAI and endometrial cancer risk in individuals aged <60 years and those with obesity, with no interaction effects by age or race (P>0.05). Conclusion Synergistic intakes of dietary antioxidants are associated with a reduced risk of uterinecancer. Among them, the synergistic intake of vitamin C, E, and zinc has potential preventive significance.

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composite dietary antioxidant index / NHANES / gynecological cancers / uterine cancer / cross-sectional study

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YAN Yu-qing, XU Ming-dan, YANG Liu, BO Ya-cong, LYU Quan-jun. ASSOCIATION BETWEEN COMPOSITE DIETARY ANTIOXIDANT INDEX AND GYNECOLOGICAL CANCERS: A CROSS-SECTIONAL ANALYSIS OF THE DATA FROM NHANES 2013–2023[J]. Acta Nutrimenta Sinica. 2025, 47(5): 439-445

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