HYPOLIPIDEMIC EFFECT OF CORDYCEPIN AND UNDERLYING MECHANISMS: PROGRESS IN EXPERIMENTAL STUDIES

BI Yong-hui; LI Xi; YANG Dan-feng

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Acta Nutrimenta Sinica ›› 2025, Vol. 47 ›› Issue (6) : 612-617.

CRITICAL REVIEWS

HYPOLIPIDEMIC EFFECT OF CORDYCEPIN AND UNDERLYING MECHANISMS: PROGRESS IN EXPERIMENTAL STUDIES

BI Yong-hui^1,2, LI Xi², YANG Dan-feng²

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Abstract

Dyslipidemia is closely associated with the development of cardiovascular diseases. Cordycepin, a key bioactive compound derived from the medicinal fungus Cordyceps militaris, shows promising potential in regulating lipid metabolism. Current experimental evidence indicates its beneficial effects on improving blood lipid profiles. We summarize research progress in the hypolipidemic action of cordycepin based on experimental studies. Its underlying mechanisms are also explored, including inhibition of lipid synthesis, promotion of fatty acid oxidation, modulation of the gut microbiota-short-chain fatty acid axis, and amelioration of oxidative stress, metabolic inflammation, and autophagy homeostasis.

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cordycepin / dyslipidemia / lipid metabolism / mechanisms of action

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BI Yong-hui, LI Xi, YANG Dan-feng. HYPOLIPIDEMIC EFFECT OF CORDYCEPIN AND UNDERLYING MECHANISMS: PROGRESS IN EXPERIMENTAL STUDIES[J]. Acta Nutrimenta Sinica. 2025, 47(6): 612-617

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