RESEARCH PROGRESS ON THE MECHANISMS OF HYPOXIA-INDUCED COGNITIVE IMPAIRMENT AND INTERVENTION BY PHYTOCHEMICALS

LIU Ya-nan; MAO Pei-yu; HE Shu-fan; JIANG Yu-gang

Acta Nutrimenta Sinica ›› 2026, Vol. 48 ›› Issue (2) : 200-205.

LIU Ya-nan^1,2, MAO Pei-yu^1,2, HE Shu-fan^1,2, JIANG Yu-gang¹

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Abstract

Hypoxia-induced cognitive impairment is mainly manifested by declines in attention as well as learning and memory abilities. The underlying mechanisms primarily involve oxidative stress, alterations in blood-brain barrier permeability, calcium homeostasis imbalance, and disturbances in energy metabolism. In recent years, accumulating evidence has demonstrated that various phytochemicals, including flavonoids (quercetin, catechins, and epigallocatechin gallate), terpenoids (ginkgolides and crocin), and polysaccharides (Astragalus polysaccharides and Lycium barbarum polysaccharides), can significantly alleviate hypoxia-induced cognitive dysfunction and exert neuroprotective effects through multiple mechanisms, including antioxidant and anti-inflammatory actions, regulation of mitochondrial function, and improvement of energy metabolism. These phytochemicals are therefore considered promising in the interventions of hypoxia-induced cognitive impairment. This review focuses on the mechanisms underlying hypoxia-induced cognitive dysfunction and summarizes recent advances in the effects of representative phytochemicals on hypoxia-related cognitive impairment, providing a theoretical basis for the development of functional foods and intervention strategies.

Key words

hypoxic environment / cognitive function / neuroprotection / phytochemicals

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LIU Ya-nan, MAO Pei-yu, HE Shu-fan, JIANG Yu-gang. RESEARCH PROGRESS ON THE MECHANISMS OF HYPOXIA-INDUCED COGNITIVE IMPAIRMENT AND INTERVENTION BY PHYTOCHEMICALS[J]. Acta Nutrimenta Sinica. 2026, 48(2): 200-205

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