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中国应用生理学杂志 ›› 2017, Vol. 33 ›› Issue (6): 526-530.doi: 10.12047/j.cjap.5601.2017.125

• 研究论文 • 上一篇    下一篇

超敏C反应蛋白与阵发性房颤射频消融术后早期复发的关系

赵月香1, 单兆亮2, 郭红阳2, 林琨2, 国建萍2, 王玉堂1   

  1. 1. 解放军总医院南楼心血管内科, 北京 100853;
    2. 解放军总医院心血管内科, 北京 100853
  • 收稿日期:2017-04-10 修回日期:2017-10-14 出版日期:2017-11-28 发布日期:2018-06-19
  • 基金资助:
    军队保健专项课题(11BJZ10)

The relationship between high-sensitivity C-reactive protein (hsCRP) levels and atrial fibrillation early recurrence after paroxysmal atrial fibrillation radiofrequency catheter ablation

ZHAO Yue-xiang1, SHAN Zhao-liang2, GUO Hong-yang2, LIN Kun2, GUO Jian-ping2, WANG Yu-tang1   

  1. 1. Department of Cardiology, Nanlou Clinal Division of PLA General Hospital, Beijing 100853, China;
    2. Department of Cardiovascular Medicine of PLA General Hospital, Beijing 100853, China
  • Received:2017-04-10 Revised:2017-10-14 Online:2017-11-28 Published:2018-06-19
  • Contact: 王玉堂,Tel:010-66876291;E-mail:wvt301@sina.com E-mail:wvt301@sina.com
  • Supported by:
    军队保健专项课题(11BJZ10)

摘要: 目的:前瞻性研究超敏C反应蛋白(hsCRP)与阵发性心房颤动射频消融术后早期复发的关系。方法:接受CARTO指导房颤射频消融术的非瓣膜性阵发性房颤患者57例,平均年龄(53.32±9.98)岁,其中男42例,女15例。术前及术后5 d连续测定外周血hsCRP和高敏肌钙蛋白T (hs-cTnT)水平,记录体表心电图,行24 h动态心电图检查。术后5 d内,32名患者(56.14%)为窦性心律,为未复发组,25名(43.86%)复发房颤,为复发组。结果:未复发组与复发组患者的hsCRP与hs-cTnT日均升高量显著正相关,P=0.044,r=0.268。而两组间基线临床特征、手术前后血浆hsCRP、hs-cTnT水平、血浆hsCRP及hs-cTnT的总升高量(峰值水平-术前水平)、日均升高量(总升高量/达到峰值所用天数)无明显统计学差异(P均>0.05)。结论:房颤射频消融术后hsCRP升高变化与心肌损伤程度相关,与早期复发无直接关系,尚不能作为预测房颤术后早期复发的高危因子。

关键词: 心房颤动, 超敏C反应蛋白, 肺静脉隔离术, 早期复发

Abstract: Objective: To prospectively clarify the predictive value of high-sensitivity C-reactive protein (hsCRP) on the risk for recurrent atrial arrhythmia in paroxysmal atrial fibrillation (PAF) population who accepted radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF).Methods: There were 57 consecutive patients (53.32±9.98 years; 42 males) with drug-refractory PAF who underwent RFCA were included. Plasma levels of hsCRP and high-sensitivity cardiac troponin T (hs-cTnT) were measured on admission and first five days after RFCA. Twenty-five patients (43.86%) had early recurrence of atrial fibrillation (ERAF).Results: Compared to patients without ERAF (no-AF-recurrence group), baseline hsCRP levels had no significant difference in patients with ERAF (AF recurrence group). There were no significant differences in the peak hsCRP and hs-cTnT levels between no-AF-recurrence group and AF recurrence group. However, change of hsCRP level was significantly correlated with change in hs-cTnT level in patients undergoing RFCA (r=0.268, P=0.044).Conclusion: Among those AF patients undergoing ablation, change of hsCRP level could be for the myocardial injury related to RFCA procedure, which may not be a risk factor to predict ERAF. The variety of hsCRP level may be related to the degree of myocardial injury induced by RFCA.

Key words: atrial fibrillation, high-sensitivity C-reactive protein (hsCRP), circumferential pulmonary vein isolation (CPVI), early recurrence

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