Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor

doi:10.13459/j.cnki.cjap.2016.06.003

中国应用生理学杂志 ›› 2016, Vol. 32 ›› Issue (6): 494-498.doi: 10.13459/j.cnki.cjap.2016.06.003

Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor

Xiao-min LUO^1,2, Lei WANG¹, Lei YANG¹

1. Tibet Branch, Beijing Genomics Institute, Lhasa 850032, China;
2. Healthcare Dept., Beijing Genomics Institute, Shenzhen 518083, China

收稿日期:2016-07-23 修回日期:2016-10-24 出版日期:2016-11-28 发布日期:2018-06-19
通讯作者: Xiao-ming LUO,Principal Investigator,Tibet Branch,Beijing Genomics Institute,189 Jinzhu Road,Lhasa 850032,China.Tel/Fax:86-891-6618661;E-mail:luo.xiaomin@139.com E-mail:luo.xiaomin@139.com

Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor

Xiao-min LUO^1,2, Lei WANG¹, Lei YANG¹

1. Tibet Branch, Beijing Genomics Institute, Lhasa 850032, China;
2. Healthcare Dept., Beijing Genomics Institute, Shenzhen 518083, China

Received:2016-07-23 Revised:2016-10-24 Online:2016-11-28 Published:2018-06-19

摘要/Abstract

摘要： Objective: Vascular tone had shown the potential susceptibility to acute mountain sickness (AMS), however the detailed tendency has not been studied. Methods: Vascular tone, SpO₂ and Rate pressure product (RPP) were studied in seventeen healthy subjects before and after rapid ascent from sea level to 3658 m. Human acute mountain sickness was evaluated by the Lake Louise Score (LLS). Results: Nine of the seventeen participants were diagnosed with AMS. On initial exposure, there was a significant decrease in vascular tone between subjects with and without AMS. Significance was also found in the decrease of SpO₂ before and after rapid ascent but the differences between subjects with and without AMS did not reach significance during the initial phase. Conclusions:Vascular tone on initial exposure in response to rapid ascent is a possible sign of susceptibility to AMS. Conclusion: measurement of vascular tone using a wearable sensor throughout the acute phase response will provide numerical values of pathophysiology throughout the development of AMS.

关键词: vascular tone, reflection index, acute mountain sickness, susceptibility, photoplethysmographic sensor

Abstract: Objective: Vascular tone had shown the potential susceptibility to acute mountain sickness (AMS), however the detailed tendency has not been studied. Methods: Vascular tone, SpO₂ and Rate pressure product (RPP) were studied in seventeen healthy subjects before and after rapid ascent from sea level to 3658 m. Human acute mountain sickness was evaluated by the Lake Louise Score (LLS). Results: Nine of the seventeen participants were diagnosed with AMS. On initial exposure, there was a significant decrease in vascular tone between subjects with and without AMS. Significance was also found in the decrease of SpO₂ before and after rapid ascent but the differences between subjects with and without AMS did not reach significance during the initial phase. Conclusions:Vascular tone on initial exposure in response to rapid ascent is a possible sign of susceptibility to AMS. Conclusion: measurement of vascular tone using a wearable sensor throughout the acute phase response will provide numerical values of pathophysiology throughout the development of AMS.

Key words: vascular tone, reflection index, acute mountain sickness, susceptibility, photoplethysmographic sensor

Xiao-min LUO, Lei WANG, Lei YANG. Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor[J]. 中国应用生理学杂志, 2016, 32(6): 494-498.

Xiao-min LUO, Lei WANG, Lei YANG. Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor[J]. CJAP, 2016, 32(6): 494-498.

参考文献

1. Maggiorini M, Buhler B, Walter M, et al. Prevalence of acute mountain sickness in the Swiss Alps[J]. BMJ, 1990, 301(6756):853-855.
2. Muza SR, Beidleman BA, Fulco CS. Altitude preexposure recommendations for inducing acclimatization[J]. High Alt Med Biol, 2010, 11(2):87-92.
3. Hackett PH, Roach RC. High-altitude illness[J]. New Engl J Med, 2001, 345(2):107-114.
4. Roach RC, Hackett PH. Frontiers of hypoxia research:acute mountain sickness[J]. J Exp Biol, 2001, 204(Pt 18):3161-3170.
5. Imray C, Wright A, Subudhi A, et al. Acute mountain sickness:pathophysiology, prevention, and treatment[J]. Prog Cardiovasc Dis, 2010, 52(6):467-484.
6. Gomersall T. Acute mountain sickness[J]. Scottish Univ Med J, 2012, 1(1):98-103.
7. Chen HC, Lin WL, Wu JY, et al. Change in oxygen saturation does not predict acute mountain sickness on jade mountain[J]. Wilderness Environ Med, 2012, 23(2):122-127.
8. Leichtfried V, Basic D, Burtscher M, et al. Diagnosis and prediction of the occurrence of acute mountain sickness measuring oxygen saturation-independent of absolute altitude[J]? Sleep Breath, 2016, 20(1):435-442.
9. Wagner DR, Knott JR, Fry JP. Oximetry fails to predict acute mountain sickness or summit success during a rapid ascent to 5 640 meters[J]. Wilderness Environ Med, 2012, 23(2):114-121.
10. Kanstrup IL, Poulsen TD, Hansen JM, et al. Blood pressure and plasma catecholamines in acute and prolonged hypoxia:effects of local hypothermia[J].J Appl Physiol, 1999, 87(6):2053-2058.
11. Boos CJ, Hodkinson P, Mellor A, et al. The effects of acute hypobaric hypoxia on arterial stiffness and endothelial function and its relationship to changes in pulmonary artery pressure and left ventricular diastolic function[J]. High Alt Med Biol, 2012, 13(2):105-111.
12. Rhodes HL, Chesterman K, Chan CW, et al. Systemic blood pressure, arterial stiffness and pulse waveform analysis at altitude[J]. J R Army Med Corps, 2011, 157(1), 110-113.
13. Morganti A, Giussani M, Sala C, et al. Effects of exposure to high altitude on plasma endothelin-1 levels in normal subjects[J]. J Hyperten, 1995, 13(8):859-865.
14. Barthelemy JC, Lacour JR, Roche F, et al. Elevated nocturnal blood pressure assessed by ambulatory automatic monitoring during a stay at high altitude[J]. Eur J Appl Physiol Occup Physiol, 1995, 70(3):258-262.
15. Basu CK, Gautam RK, Sharma RP, et al. Metabolic responses during initial days of altitude acclimatization in the eastern Himalayas[J]. Int J Biometeorol, 1996, 39(3):133-138.
16. Bernardi L, Passino C, Spadacini G, et al. Cardiovascular autonomic modulation and activity of carotid baroreceptors at altitude[J]. Clin Sci (Lond), 1998, 95(5):565-573.
17. Drinkwater BL, Kramar PO, Bedi JF, et al. Women at altitude:cardiovascular responses to hypoxia[J]. Aviat Space Environ Med, 1982, 53(5):472-477.
18. Rupwate RU, Chitaley M, Kamat SR. Cardiopulmonary functional changes in acute acclimatisation to high altitude in mountaineers[J]. Eur J Epidemiol, 1990, 6(3):266-272.
19. Korner PI. Circulation adaptation in hypoxia[J]. Physiol Rev, 1959, 39(4):687-730.
20. Stenberg J, Ekblom B, Messin R. Hemodynamic response to work at simulated altitude, 4 000 m[J]. J Appl Physiol, 1966, 21(5):1589-1594.
21. Aigner A, Berghold F, Muss N. Investigations on the cardiovascular system at altitudes up to a height of 7 800 meters[J]. Z Kardiol, 1980, 69(9):604-610.
22. Passino C, Bernardi L, Spadacini G, et al. Autonomic regulation of heart rate and peripheral circulation:comparison of high altitude and sea level residents[J]. Clin Sci(Lond), 1996, 91(suppl):81-83.
23. Luo X, Wang L, Yang L. Effects of rapid ascent to high altitude on vascular tone[C]//2015 7th International Conference on Information Technology in Medicine and Education (ITME). IEEE, 2015:103-107.
24. Luo X, Wang L, Yang L. Influence of induced altitude acclimatization on development of acute mountain sickness associated with a subsequent rapid ascent to high altitude[C]//2016 16th International Conference on BioInformatics and BioEngineering (BIBE). IEEE, 2016:289-292.
25. Droma Y, Hayano T, Takabayashi Y, et al. Endothelin-1 and interleukin-8 in high altitude pulmonary edema[J]. Eur Respir J, 1996, 9(9):1947-1949.
26. Blitzer ML, Loh E, Roddy MA, et al. Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans[J]. J Am Coll Cardiol, 1996, 28(3):591-596.
27. Carroll D, Ring C, Shrimpton J, et al. Secretory immunoglobulin A and cardiovascular responses to acute psychological challenge[J]. Inte J Behav Med, 1996, 3(3):266-279.
28. Othman M, Kawar B, El Nahas AM. Influence of obesity on progression of non-diabetic chronic kidney disease:a retrospective cohort study[J]. Nephron Clin Pract, 2009, 113(1):c16-c23.
29. Shah AM, Mebazaa A, Yang ZK, et al. Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells a potential mechanism for matching oxygen supply and demand[J]? Circ Res, 1997, 80(5):688-698.
30. Su F, Li Z, Sun X, et al. The pulse wave analysis of normal pregnancy:investigating the gestational effects on photoplethysmographic signals[J]. Biomed Mater Eng, 2014, 24(1):209-219.
31. Han N, Luo X, Su F. A quantitative investigation of hemodynamic adaptation to pregnancy using uterine artery Doppler ultrasonography and finger photoplethysmography[J]. Hypertens Pregnancy, 2014, 33(4):498-507.
32. Lyu Y, Luo X, Zhou J, et al. Measuring photoplethysmogram-based stress-induced vascular response index to assess cognitive load and stress[C]//Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems. ACM, 2015:857-866.
33. Liu Z, Zhou Y, Yi R, et al. Quantitative research into the deconditioning of hemodynamic to disorder of consciousness carried out using transcranial Doppler ultrasonography and photoplethysmography obtained via finger-transmissive absorption[J]. Neurol Sci, 2016, 37(4):547-555.
34. Scholze A, Burkert A, Mardanzai K, et al. Increased arterial vascular tone during the night in patients with essential hypertension[J]. J Hum Hypertens, 2007, 21(1):60-67.

Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor

Identification of susceptibility to acute mountain sickness by detecting vascular tone using a photoplethysmographic sensor

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