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中国应用生理学杂志 ›› 2016, Vol. 32 ›› Issue (6): 519-524.doi: 10.13459/j.cnki.cjap.2016.06.008

• 研究论文 • 上一篇    下一篇

Changes in oxygen saturation can not help diagnose acute mountain sickness (AMS): ascending to Lhasa on the Qinghai-Tibet train

Jun-bo AN1,2,3, Hao-ran GU4, Yu WU1,3, Yong-jun LUO1,3   

  1. 1. Department of Military Medical Geography, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China;
    2. Battalion;
    5 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China;
    3. Key Laboratory of High Altitude Medicine(Ministry of Education), Third Military Medical University, Chongqing 400038, China;
    4. The 12th hospital of PLA, Kashi 844200, China
  • 收稿日期:2016-09-20 修回日期:2016-10-19 出版日期:2016-11-28 发布日期:2018-06-19
  • 通讯作者: Yong-jun LUO,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China;Tel:86 23 6875 2396;Fax:86 23 6875 2396;E-mail:luoyongjun2011@gmail.com E-mail:luoyongjun2011@gmail.com

Changes in oxygen saturation can not help diagnose acute mountain sickness (AMS): ascending to Lhasa on the Qinghai-Tibet train

Jun-bo AN1,2,3, Hao-ran GU4, Yu WU1,3, Yong-jun LUO1,3   

  1. 1. Department of Military Medical Geography, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China;
    2. Battalion;
    5 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China;
    3. Key Laboratory of High Altitude Medicine(Ministry of Education), Third Military Medical University, Chongqing 400038, China;
    4. The 12th hospital of PLA, Kashi 844200, China
  • Received:2016-09-20 Revised:2016-10-19 Online:2016-11-28 Published:2018-06-19

摘要: Objective: Acute mountain sickness (AMS) is a common condition in individuals who ascend to altitudes over 2 500 m. There is no measurements that can reliably predict or diagnose this condition. We therefore determined whether pulse oximetry data are associated with the development of AMS and can help diagnose AMS. Methods: We studied 58 young male undergraduates who traveled from Chongqing (300 m) to Lhasa (3 658 m) by train. We collected data on the ascent profiles and AMS symptoms based on the Lake Louise Score (LLS). The resting arterial oxygen saturation (R-SpO2) and pulse rate were then measured using finger pulse oximetry. Results: In Golmud(2 800 m) and Tanggula(5 200 m), R-SpO2 was significantly lower in the AMS group than in the group without AMS (P<0.05). However, upon arrival in Lhasa (3 658 m), the R-SpO2 was higher in the AMS group than in the non-AMS group (P<0.05). In Tanggula, the change in the SpO2 (CR-SpO2) in the AMS group was higher than that in the non-AMS group (P<0.05). But in Lhasa, the CR-SpO2 in the AMS group was lower than that in the non-AMS group (P<0.05). We also monitored heart rate (HR) throughout the study. In Xining(2 200 m) and Golmud, the HRs in the AMS group were higher than those in the non-AMS group. However, the HRs in the AMS group were lower than those in the non-AMS group in Tanggula and Lhasa. Conclusion: Based on the results of this study, the R-SpO2 graph was not consistent. We can thus conclude that the utility of SpO2 remains limited in the diagnosis of AMS. The results suggest that using pulse oximetry to diagnose AMS is not valuable in people ascending to Lhasa on the Qinghai-Tibet train.

关键词: acute mountain sickness, oxygen saturation, heart rate, altitude

Abstract: Objective: Acute mountain sickness (AMS) is a common condition in individuals who ascend to altitudes over 2 500 m. There is no measurements that can reliably predict or diagnose this condition. We therefore determined whether pulse oximetry data are associated with the development of AMS and can help diagnose AMS. Methods: We studied 58 young male undergraduates who traveled from Chongqing (300 m) to Lhasa (3 658 m) by train. We collected data on the ascent profiles and AMS symptoms based on the Lake Louise Score (LLS). The resting arterial oxygen saturation (R-SpO2) and pulse rate were then measured using finger pulse oximetry. Results: In Golmud(2 800 m) and Tanggula(5 200 m), R-SpO2 was significantly lower in the AMS group than in the group without AMS (P<0.05). However, upon arrival in Lhasa (3 658 m), the R-SpO2 was higher in the AMS group than in the non-AMS group (P<0.05). In Tanggula, the change in the SpO2 (CR-SpO2) in the AMS group was higher than that in the non-AMS group (P<0.05). But in Lhasa, the CR-SpO2 in the AMS group was lower than that in the non-AMS group (P<0.05). We also monitored heart rate (HR) throughout the study. In Xining(2 200 m) and Golmud, the HRs in the AMS group were higher than those in the non-AMS group. However, the HRs in the AMS group were lower than those in the non-AMS group in Tanggula and Lhasa. Conclusion: Based on the results of this study, the R-SpO2 graph was not consistent. We can thus conclude that the utility of SpO2 remains limited in the diagnosis of AMS. The results suggest that using pulse oximetry to diagnose AMS is not valuable in people ascending to Lhasa on the Qinghai-Tibet train.

Key words: acute mountain sickness, oxygen saturation, heart rate, altitude

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