2623名患者红细胞不规则抗体筛选结果分析*

doi:10.12047/j.cjap.5807.2019.099

中国应用生理学杂志 ›› 2019, Vol. 35 ›› Issue (5): 457-459.doi: 10.12047/j.cjap.5807.2019.099

2623名患者红细胞不规则抗体筛选结果分析^*

解金辉^△, 种靖慧, 黄娴, 王维, 董峥, 李彤彤, 李立新, 吴丽娜

天津市血液中心, 天津 300110

收稿日期:2019-01-11 出版日期:2019-09-28 发布日期:2020-01-02
通讯作者: ^△Tel: 13502026605; E-mail: xie_jinhui@163.com

Received:2019-01-11 Online:2019-09-28 Published:2020-01-02

摘要/Abstract

摘要： 目的:对红细胞抗体筛选阳性的标本进行红细胞不规则抗体特异性鉴定与分析,为临床安全输血提供帮助。方法:2011年8月至2018年12月天津市各医院送至本中心实验室检测的2623份血液标本,进行红细胞不规则抗体筛选和鉴定;采用低离子强度溶液-抗人球蛋白微柱凝胶卡方法和盐水直接离心方法进行抗体筛选和抗体鉴定。结果:共检出2744个红细胞抗体,其中2139个为同种抗体,509个为自身抗体,96份标本未能确定抗体特异性;在所检出的同种抗体中,Rh系统的抗体最常见,占比为54.7％(其中抗-E 26.2％,抗-c 8.7％,抗-C 7.7％,抗-e 6.9％,抗-D 4.9％),MNS系统、Lewis系统、Kidd系统、P系统、Duffy系统、Kell系统、Diego系统均有抗体检出。结论:在输血前检测中,为预防检出不规则抗体的情况出现,应提前备血,以免由此导致的延迟输血,影响治疗。

关键词: 红细胞同种抗体, 不规则抗体, 血清学试验

Key words: alloantibody, red blood cell, irregular erythrocyte antibody, serological test

解金辉, 种靖慧, 黄娴, 王维, 董峥, 李彤彤, 李立新, 吴丽娜. 2623名患者红细胞不规则抗体筛选结果分析^*[J]. 中国应用生理学杂志, 2019, 35(5): 457-459.

参考文献

[1] Yousuf R, Abdul Aziz S, Yusof N, et al. A rare case of anti-jk3 antibody detected on pre-transfusion investigation[J]. Indian J Hematol Blood Transfus, 2014, 30(3): 208-210.
[2] 解金辉, 种靖慧, 黄娴, 等. 1939例ABO血型系统新生儿溶血病的血型分布[J].中国应用生理学杂志, 2014, 30(4): 380-381.
[3] 吴擘颋, 姚顶根, 戎瑞明. 住院患者红细胞血型同种不规则抗体特征分析 [J]. 中华医学杂志, 2011, 91( 24 ): 1691-1693.
[4] Hassan MN, Mohd Noor NH, Johan Noor SR, et al. Hemolytic disease of fetus and newborn due to maternal red blood cell alloantibodies in the Malay population[J]. Asian J Transfus Sci, 2014, 8(2): 113－117.
[5] Reyhaneh K, Ahmad G, Gharib K, et al. Frequency and specificity of RBC alloantibodies in patients due for surgery in Iran[J]. Indian J Med Res, 2013, 138: 252-256.
[6] Xu P, Li Y, Yu H. Prevalence, specificity and risk of red blood cell alloantibodies among hospitalised Hubei Han Chinese patients[J]. Blood Transfus, 2014, 12(1): 56-60.
[7] Pahuja S, Gupta SK, Pujani M, et al. The prevalence of irregular erythrocyte antibodies among antenatal women in Delhi[J]. Blood Transfus, 2011, 9(4): 388-393.
[8] Natukunda B, Schonewille H, van de Watering L, et al. Prevalence and specificities of red blood cell alloantibodies in transfused Ugandans with different diseases[J]. Vox Sang, 2010, 98(2): 167-171.
[9] Vichinsky EP, Luban NL, Wright E, et al. Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial[J]. Transfusion, 2001, 41(9): 1086-1092.
[10]Cheng CK, Lee CK, Lin CK. Clinically significant red blood cell antibodies in chronically transfused patients: a survey of Chinese thalassemia major patients and literature review[J]. Transfusion, 2012, 52(10): 2220-2224.
[11]Zumberg MS, Procter JL, Lottenberg R, et al. Autoantibody formation in the alloimmunized red blood cell recipient: clinical and laboratory implications[J]. Arch Intern Med, 2001, 161(2): 285-290.
[12]Yu Y, Wang DQ. Effect of superposition and masking between red blood cell autoantibodies and alloantibodies[J]. Genet Mol Res, 2014, 13(2): 4666-4672.
[13]Foudoulaki-Paparizos L, Valsami S, Bournas N, et al. Alloimmunisation during pregnancy in Greece: need for nationwide HDFN prevention programme[J]. Transfus Med, 2013, 23(4): 254-259.

2623名患者红细胞不规则抗体筛选结果分析^*

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价