经颅电刺激对睡眠剥夺后双侧后扣带回皮质功能连接紊乱干预作用的初步研究*

doi:10.12047/j.cjap.5886.2020.023

中国应用生理学杂志 ›› 2020, Vol. 36 ›› Issue (2): 101-105.doi: 10.12047/j.cjap.5886.2020.023

经颅电刺激对睡眠剥夺后双侧后扣带回皮质功能连接紊乱干预作用的初步研究^*

孟晴晴^1,2, 李继元³, 郭大龙⁴, 邵永聪⁵, 张熙^1△

1.中国人民解放军总医院睡眠医学中心, 北京 100853;
2.中央军委机关事务管理总局保健处, 北京 100034;
3.首都医科大学附属北京世纪坛医院磁共振室, 北京 100038;
4.空军航空医学研究所航空医学工程研究中心, 北京 100037;
5.军事医学科学院基础医学研究所, 北京 100850

出版日期:2020-03-28 发布日期:2020-07-31
通讯作者: ^△Tel: (010)66876097; E-mail: zhangxi@301hospital.com.cn
基金资助:
^*全军“十二五”重大项目(AWS14J011)

The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study

MENG Qing-qing^1,2, LI Ji-yuan³, GUO Da-long⁴, SHAO Yong-cong⁵, ZHANG Xi^1△

1. Department of Geriatric Neurology, Sleep Medicine Research Center, the General Hospital of the People's Liberation Army, Beijing 100853;
2. Departmengt of Health Administration of the Central Military Commission, Beijing 100034;
3. Department of MRI, Beijing Shijitan Hospital Capital Medical University, Beijing 100038;
4. Air Force Institute of Aviation Medicine, Aviation Medical Engineering Research Center, Beijing 100037;
5. Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing 100850, China

Online:2020-03-28 Published:2020-07-31

摘要/Abstract

摘要： 目的: 探讨经颅电刺激对睡眠剥夺后双侧后扣带回皮质功能连接紊乱的干预作用。方法: 研究采用自身前后对照的试验设计。16名受试者均接受2次24 h睡眠剥夺,2次睡眠剥夺间隔3周,受试者分别于第1次正常睡眠后、24 h睡眠剥夺后、经颅电刺激(真或假刺激)干预后(真、假刺激电流大小均为1 mA,电流作用时间分别为20 min、2 s,干预实验均持续20 min)及第2次经颅电刺激(假或真刺激)干预后采集静息态磁共振成像数据。以睡眠剥夺前收集静息态功能磁共振数据作为基线,选取双侧后扣带回皮质作为种子点进行全脑功能连接分析,观察睡眠剥夺前后及经颅电刺激真、假刺激后大脑的功能连接变化。结果: 与正常睡眠后相比,24 h睡眠剥夺后双侧后扣带回皮质与双侧丘脑间的功能连接上升(P＜0.01),与右侧楔前叶、海马旁回以及双侧岛叶间的功能下降(P＜0.01)。与假刺激相比,给予真刺激后左侧后扣带回皮质与右侧楔前叶功能连接上升(P＜0.01);与双侧丘脑、岛叶及右侧大脑皮质功能连接下降(P＜0.01)。右侧后扣带回皮质与全脑的功能连接在双侧丘脑、右侧岛叶及大脑皮层间也存在下降(P＜0.01)。结论: 24 h睡眠剥夺可引起双侧后扣带回功能连接紊乱,而经颅电刺激可在一定程度上改善睡眠剥夺后的功能连接紊乱。

关键词: 经颅电刺激, 睡眠剥夺, 静息态功能磁共振成像, 功能连接, 后扣带回皮质

Abstract: Objective: To investigate the effects of transcranial direct current stimulation (tDCS) on the disturbance of brain network dysfunction after sleep deprivation (SD). Methods: The experimental design of self-control was used in the study. All 16 subjects received 2 times of 24 h SD with an interval of 3 weeks. After the first normal sleep, 24 h SD and transcranial electrical stimulation (true or false stimulation) intervention (the current magnitude of true and false stimulation was 1 mA, and the action time was 20 min and 2 s, respectively. The intervention experiment lasted for 20 min. ) and the resting magnetic resonance imaging data were collected after the second transcranial electrical stimulation (sham or true stimulation). The resting fMRI data were collected as baseline before SD, the bilateral posterior cingulate cortex in the default mode network was selected as the seed point, and the functional connectivity between the seed points and the whole brain was calculated. Results: Compared with the rest wakefulness, the functional connectivity among bilateral posterior cingulate cortex, bilateral thalamus and hippocampus was increased (P＜0. 01), but connected with the right precuneus, bilateral insula was decreased after 24 h SD (P＜0. 01). Compared with the sham tDCS group, the functional connectivity between left posterior cingulate cortex seed point and right precuneus of tDCS group was increased (P＜0. 01); but decreased with the bilateral thalamus, insula and right cerebral cortex (P＜0. 01). There was a decrease in the functional connectivity among the right posterior cingulate cortex and the bilateral thalamus, right insula, and cerebral cortex(P＜0. 01). Conclusion: 24-hours sleep deprivation can cause functional connection disorder of bilateral posterior cingulate gyrus, and transcranial electrical stimulation can improve the functional connection disorder after sleep deprivation to some extent.

Key words: transcranial direct current stimulation, sleep deprivation, resting state function magnetic resonance imaging, functional connectivity, posterior cingulate cortex

中图分类号:

R445.2

孟晴晴, 李继元, 郭大龙, 邵永聪, 张熙. 经颅电刺激对睡眠剥夺后双侧后扣带回皮质功能连接紊乱干预作用的初步研究^*[J]. 中国应用生理学杂志, 2020, 36(2): 101-105.

MENG Qing-qing, LI Ji-yuan, GUO Da-long, SHAO Yong-cong, ZHANG Xi. The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study[J]. CJAP, 2020, 36(2): 101-105.

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经颅电刺激对睡眠剥夺后双侧后扣带回皮质功能连接紊乱干预作用的初步研究^*

The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study

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