Abstract: Objective: To study the anti-senile effects of the Fomes officinalis flavonoids on the aging model mice. Methods: All Kun ming mice were randomly divided into six groups, and each group consisted of 12 animals. The groups were categorized as normal, model, positive control groups and low (100 mg/(kg·d)), medium (200 mg/(kg·d)), high (400 mg/(kg·d)) doses of Fomes officinalis flavonoids treated groups. The study was carried out to investigate the cerebral index, spleen index, thymus index, the contents of malondi-aldehyde (MDA) and the activities of glutathione peroxidase (GSH-Px) in brain tissues as well as the activities of catalase (CAT) and superoxide dismutase (SOD) in liver tissues of the aging model mice treated with D-galactose in vivo by subcutaneous injection together with the Fomes officinalis flavonoids at doses of 100, 200 and 400 mg/(kg·d) for 6 weeks. The normal group was administered with 0.20 ml/10 g of normal saline s.c. and 50 ml/kg of normal saline i.g. daily. Results: Compared with the aging model groups, the three doses of the Fomes officinalis flavonoids could elevate the cerebral index, spleen index, thymus index, activities of GSH-Px in brain tissues, the activities of CAT and SOD in liver tissues to different degree and decrease the contents of MDA. Conclusion: The Fomes officinalis flavonoids might have anti-senile action by improving antioxidant capacity of human body.

Key words: Fomes officinalis flavonoids, aging model mice, anti-senile, antioxidase