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CJAP ›› 2018, Vol. 34 ›› Issue (1): 4-7.doi: 10.12047/j.cjap.5567.2018.002

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Effects of CHL1 deficiency,a cell adhesion molecule,on the inflammatory bowel disease

WANG Xiao-meng1, ZHAO Tong1, CHENG Xiang1, GUO Ning1, ZHU Ling-ling1, SHI Ming2, WU Kui-wu1   

  1. 1. Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850;
    2. Jiangsu Province Cancer Biotherapy Institute, Xuzhou 221004, China
  • Received:2017-05-22 Revised:2017-10-18 Online:2018-01-28 Published:2018-06-19
  • Supported by:
    国家自然科学基金面上项目(81572845,81773086,81773258)

Abstract: Objective: To investigate the effects of deficiency of CHL1 in inflammatory bowel disease (IBD).Methods: Dextran Sulfate Sodium (DSS)-induced colitis model was used to study the effects of deficiency of CHL1 on the development of IBD. Ten CHL1(+/+) mice in C57/BL6 background were randomly divided into CHL1(+/+) group and DSS-induced CHL1(+/+) group. Ten CHL1(-/-) mice in C57/BL6 background were randomly divided into CHL1(-/-) group and DSS-induced CHL1(-/-) group. DSS-induced CHL1(+/+) group and DSS-induced CHL1(-/-)group were fed with 1.5% DSS for 7 days, and then drinking distilled water for 2 days. CHL1(+/+) group and CHL1(-/-) group as control group were fed with distilled water for 9 days. The changes of weight, survival, fecal blood and the change of colon length in this study were observed.Results: On the 7th day, the weight of DSS-induced CHL1(-/-) group were reduced significantly, and DSS-induced CHL1(-/-) group had extreme mortality on the 9th day. The fecal blood of DSS-induced CHL1(-/-) group also had higher score than that of DSS-induced CHL1(+/+) group. In the DSS-induced CHL1(-/-) group,the length of colon was shortened obviously.Conclusion: The loss of CHL1 aggravates the development of IBD.

Key words: CHL1, DSS, IBD

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