Abstract: Objective: The interpretation of control and regulation of circulatory parameters in traditional physiology has some limitations. Human being is an organic, circulatory control and regulation should involve all the systems. Methods: Based upon the theory of holistic integrative physiology and medicine,we approach to explain the circulatory control and regulation from its purpose. Results: The main purpose of circulation is to maintain a stable metabolism of cells,i.e. transport oxygen （from lung）and nutrients （from gastrointestinal tract）to cells, and return carbon dioxide and metabolic products back for elimination. Based on this goal, all respiration and gastrointestinal digestion, absorption, urinary excretion, etc. are integrative together for regulation to maintain the supply-demand balance at any metabolic status of resting, exercise and sleep. So that, we can explain many existing problems and questions, for example: why and how the foramen ovale closed after birth; mechanism of Cheyne-Stokes respiration; blood flow redistribution during exercise; variabilities of systolic blood pressure, heart rate and autonomic tone. Conclusion: The circulatory control and regulation is the integration of all systems of the body.

Key words: holistic integrative physiology and medicine theory, integrated regulation of respiratory, circulatory and metabolic axes, integrated regulation of digestive, absorptive, neuro-hormonal regulation, Cheyne-Stokes respiration, blood flow redistribution during exercise, systolic blood pressure, heart rate and autonomic tone variability, foramen ovale close after birth