Abstract: Objective: The modern systemic physiology, based on limit-understand functional classification, has significant limitation and one-sidedness. Human being is organic; we should approach the mechanism of control and regulation of breathing integrating all the systems. Methods: We use new theory of holistic integrative physiology and medicine to explain the mechanism of control and regulation of breathing. Results: Except the mean level information, the up-down “W” waveform information of arterial blood gas (ABG) is core signal to control and regulate breathing. In order to do so, we must integrate all systems together. New theory will help to explain some unanswered questions in physiology and medicine , for example: fetal does not breathing; how first breath generate; how respiratory rhythm and frequency generate, etc. Conclusion: Breathing is the sign of life. Mechanism of control and regulation of breathing has to integrate respiration, circulation, nerves, metabolism, exercise, sleep and digestion, absorption and elimination and etc altogether.

Key words: holistic integrative physiology, holistic integrative medicine, new theory system, control and regulation of breathing, circulatory and respiratory integration, respiration, circulation, metabolism