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解放军预防医学杂志  2016, Vol. 34 Issue (3): 348-350    
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驻粤战士乙型肝炎表面抗体阳性率抽样调查与接种效果分析
苏建新, 李曦, 谢晓波, 洪文艳, 于德宪, 周世明, 刘建伟, 刘乐斌*
广州军区疾病预防控制中心疾病监控科, 广州 510507
The HBsAb Level of Soldiers in Guangzhou Military Unitsand its Effect of Hepatitis B Vaccine
SU Jianxin, LI Xi, XIE Xiaobo, HONG Wenyan, YU Dexian, ZHOU Shiming, LIU Jianwei, LIU Lebin*
Department of Disease Surveillance and Control, Center for Disease Control and Prevention of Guangzhou Military Region, Guangzhou 510507, China
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摘要 目的 了解驻粤战士乙型肝炎表面抗体(HBsAb)水平,评估乙肝疫苗接种效果,为完善乙肝防治策略提供参考。方法 采用分层整群抽样方法,随机抽取3个驻粤单位已接种乙肝疫苗战士1185名,采集被调查者血液以ELISA法检测血清HBsAb,并与未接种疫苗的890名入伍新兵检测结果进行对比分析,评价疫苗接种效果。结果 1185名战士血清HBsAb阳性率为81.8%(969/1185),抗体水平不达标为15.1%(179/1185)。2013年度未接种疫苗的890名新兵乙肝表面抗体阳性率为63.9%(569/890),抗体水平不达标为23.6%(210/890)。抽检战士HBsAb阳性率和达标率(81.8%,66.7%)均明显高于未接种疫苗新兵(63.9%,40.3%)(P<0.01;X2达标率=142.59,P<0.01)。结论 血清HBsAb水平可用于乙肝疫苗接种效果评价和考核预防接种工作,应进一步开展相关研究。
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关键词 乙型肝炎乙型肝炎表面抗体乙肝疫苗预防接种    
AbstractObjective To investigate the HBsAb level of soldiers in Guangzhou military region and to evaluate the effect of hepatitis B vaccine, so as to provide the reference for hepatitis B prevention and treatment.Methods A total of 1185 soldiers with vaccination were randomly sampled from three units in Guangdong, their blood samples (5 ml per one) were got and detected by ELISA method for HBsAb level. At the same time, 890 blood samples from new recruits without vaccination in 2013 were also detected as control.Results The HBsAb positive rate of the 1185 soldiers was 81.8% (969/1185), the substandard of HBsAb level accounted for 15.1% (179/1185). The HBsAb positive rate of the 890 recruits without vaccination in 2013 was 63.9% (569/890), the substandard of HBsAb level accounted for 23.6% (210/890). The HBsAb positive rate (81.8%) and qualified rate (66.7%) of sampled soldiers were significantly higher than those of the 890 new recruits without vaccination (63.9%, 40.3%, respectively) (P<0.01).Conclusions HBsAb level can be used to evaluate the effect of hepatitis B vaccine and to find the question in hepatitis B prevention.
Key wordshepatitis B    HBsAb    hepatitis B vaccine    vaccination
     出版日期: 2016-08-30
基金资助:国家科技重大专项课题(No.2013ZX10004203)
引用本文:   
苏建新, 李曦, 谢晓波, 洪文艳, 于德宪, 周世明, 刘建伟, 刘乐斌. 驻粤战士乙型肝炎表面抗体阳性率抽样调查与接种效果分析[J]. 解放军预防医学杂志, 2016, 34(3): 348-350.
SU Jianxin, LI Xi, XIE Xiaobo, HONG Wenyan, YU Dexian, ZHOU Shiming, LIU Jianwei, LIU Lebin. The HBsAb Level of Soldiers in Guangzhou Military Unitsand its Effect of Hepatitis B Vaccine. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(3): 348-350.
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