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| Effect of Niaoduqing Combined with Compound Alpha-keto Acid Tablets on Calcium-phosphorus Metabolism in Patients with Maintenance Hemodialysis |
| LIU Naiquan,SUN Guangping |
| Department of Nephrology, Shengjing Hospital, China Medical University, Shenyang 110004, China |
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Abstract Objective To observe the effect of Niaoduqing (NDQ) combined with compound α-keto acid (CAA) tablets on calcium (Ca)-phosphorus (P) metabolism in patients with maintenance hemodialysis.Methods A total of 188 patients with end-stage renal disease (ESRD) during September 2013 and December 2014 were randomly divided into control group (routine therapy including maintenance hemodialysis and symptomatic treatment,n= 47),and three treatment group (drug intervention based routine therapy for 6 months, each n=47):NDQ group(5g NDQ tid),CAA group(5 tablets CAA tid),NDQ+CAA group(5g NDQ tid plus 5 tablets CAA tid).The indexes of Ca-P metabolism and serum creatinine(Cr),blood urea nitrogen(BUN),and albumn(Alb) were detected before and after treatment.Results The indexes of Ca-P metabolism, Cr,BUN, and Alb had no significant change after treatment in control group (P>0.05).NDQ and CAA alone showed effects in decreasing the level of serum P,Ca-P product and PTH after treatment.Serum P and PTH decreased significantly after treatment compared to before treatment in NDQ+CAA group,and which was most effective among 4 groups.Serum Cr,BUN, Alb had no significant change after treatment in NDQ group and CAA group.The effects of decreasing BUN and increasing Alb were better in NDQ+CAA group than other three groups(P<0.05).Conclusion NDQ combined with CAA can play a role in regulating Ca-P metabolism of ESRD patients,decrease BUN,and improve nutritional status.The combination of NDQ with CAA has better effect than use alone.
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Published: 01 September 2016
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2016, Vol. 34 
