真菌性眼内炎患者致病菌分布特征及耐药性分析

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Abstract Objective To analyze characteristics of pathogenic bacteria distribution and drug resistance of mycotic endophthalmitis patients.Methods Ninety-eight cases of mycotic endophthalmitis treated in our hospital between January 2012 and December 2014 were selected as subjects, whose general information, bacterial culture and drug resistance were retrospectively analyzed.Results Blastocystis, eurotium, fusarium and candida accounted for 38.78%, 25.51%, 19.39% and 9.18% of the pathogenic bacteria respectively. In terms of distribution of bacteria, candida albicans (19.39%), aspergillus fumigatus (11.22%) and fusarium solani (10.20%) were the most common. Drug sensitivity results showed that candida albicans had a high resistance rate to fluconazol (72.00%), itraconazole (52.00%) and 5-flucytosine (48.00%), aspergillus fumigatus had a higher resistance rate to miconazole (90.91%%) and 5-flucytosine (72.73%), fusarium solani had a higher resistance rate to itraconazole (70.00%), and that miconazole (50.00%), aspergillus flavus had a higher resistance rate to miconazole(55.56%) and 5-flucytosine(33.33%) respectively. Main pathogenic bacteria had a low resistance rate to natamycin, dualism toxin B, terbinafine, ketoconazole and voriconazole.Conclusion The pathogenic bacteria spectrum of mycotic endophthalmitis is wide, including blastocystis, eurotium, fusarium and candida. Main pathogenic bacteria have a high resistance rate to itraconazole, miconazole and 5-flucytosine.

Key words： mycotic endophthalmitis pathogenic bacteria drug resistance

Received: 21 April 2016 Published: 05 January 2017

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/ OR http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/Y2016/V34/I6/861

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