胃肠病患者幽门螺杆菌感染状况及耐药性分析

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Abstract Objective To investigate the Helicobacter pylori (Hp) infection and drug resistance in patients with gastrointestinal diseases.Methods 364 cases of patients with gastrointestinal diseases who were treated in our hospital between October 2013 and October 2015 were selected as subjects. The mucosa tissues of the gastric antrum were collected from each of these patients to perform Hp detection beforethe influencing factors were analyzed. The drug sensitivity test for isolated strains was carried out by the critical point agar dilution method. Results Among the 364 patients with gastrointestinal diseases, the rate of Hp infection was 44.78%.The Hp positive rate of gastric cancer was the highest(55.26%)among gastrointestinal diseases, followed by duodenal ulcer (50.0%),gastric ulcer (48.48%) and chronic gastritis (36.36%). Univariate analysis showed that an education level below high school, smoking or drinking, preference for hot and spicy food and overeating were risk factors for Hp infection (P<0.05)while multivariate Logistic regression analysis showed that the risk factors of Hp infection were the level of education, eating habits, spicy food, smoking and drinking. The OR values were 0.748, 0.838, 1.469 and 1.345 respectively. The drug sensitive test showed that the drug resistance of Hp to metronidazole was the highest (90.18%), followed by levofloxacin (68.71%) and clarithromycin (51.53%). There was no resistance to amoxicillin, gentamicin and furaxone.Conclusion The HP infection rate among patients with gastrointestinal diseases is relatively higher. Its occurrence is significantly correlated with eating habits, levels of education and other factors. HP has high drug resistance to metronidazole, levofloxacin and other antimicrobial drugs.

Key words： gastrointestinal disease helicobacter pylori drug resistance risk factors

Received: 22 March 2016 Published: 05 January 2017

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	XUE Zhenlong

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XUE Zhenlong. Helicobacter Pylori Infection and Drug Resistance in Patients with Gastrointestinal Diseases[J]. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(6): 872-875.

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/ OR http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/Y2016/V34/I6/872

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