目的 比较脐静脉和脐动脉血清中维生素水平的差异,分析脐静脉和脐动脉血清中维生素水平与新生儿出生体重的关联。方法 选取2021年6–9月在江苏省丹阳市人民医院住院分娩的101对母婴作为研究对象;娩出胎儿后,采集新生儿脐静脉血和脐动脉血,采用液相色谱质谱联用技术检测脐静脉和脐动脉血清中维生素A、维生素B1、维生素B2、烟酰胺、叶酸、维生素D、维生素E、维生素K1水平,采用电化学发光法检测脐血维生素B12水平;配对比较脐动脉和脐静脉血清维生素水平,并采用线性回归分析脐动脉和脐静脉血清维生素水平与出生体重的关系。结果 脐静脉血清中5-甲基四氢叶酸、维生素B2、烟酰胺、维生素A、维生素E、25-(OH)D3的水平高于脐动脉,维生素B1的水平低于脐动脉;在校正血清白蛋白水平后,脐静脉血中维生素B2、维生素A、维生素E、25-(OH)D3水平高于脐动脉血,维生素B12、叶酸、维生素B1的水平低于脐动脉血;线性回归结果显示,调整孕期增重、新生儿性别、孕周等因素后,脐静脉和脐动脉血清中维生素A的对数值均与出生体重正相关,脐静脉和脐动脉血清中维生素水平的差值在调整前后均与出生体重无统计学关联。结论 脐静脉和脐动脉血清维生素水平存在差异,脐静脉血和脐动脉血清中维生素A与新生儿出生体重正相关。
Abstract
Objective To compare the difference of serum vitamin levels in umbilical vein and artery, and to analyze the relationship between serum vitamin levels in umbilical vein and artery and birth weight. Methods A total of 101 pairs of mothers and infants who were hospitalized in Danyang People's Hospital, Jiangsu Province from June to September, 2021 were recruited as the research participants. After delivery, umbilical vein and artery blood samples of the newborns were collected. The levels of vitamin A, vitamin B1, vitamin B2, niacinamide, folic acid, vitamin D, vitamin E and vitamin K1 were detected by liquid chromatography and mass spectrometry (LC-MS/MS). The level of vitamin B12 was detected by electrochemical luminescence method. The serum vitamin levels of umbilical artery and vein were compared by matching method, and the relationship between birth weight and the serum vitamin levels of umbilical artery and vein was analyzed by linear regression. Results The levels of 5-methyltetrahydrofolate, vitamin B2, niacinamide, vitamin A, vitamin E, 25-(OH) D3 in the serum of umbilical vein were higher than those in the serum of umbilical artery, and the level of vitamin B1 was lower. After correcting for serum albumin levels, the levels of vitamin B2, vitamin A, vitamin E and 25-(OH) D3 in the serum of umbilical vein were higher than those in the serum of umbilical artery, and the levels of vitamin B12, folic acid and vitamin B1 were lower. Linear regression results showed that after adjusting for pregnancy weight gain, newborn sex, gestational age, the logarithmic value of vitamin A in the serum of umbilical vein and artery was positively correlated with birth weight, while the difference of vitamin A levels between umbilical vein and artery was not statistically correlated with birth weight before and after adjustment. Conclusion There were differences in serum vitamin levels between umbilical vein and artery. Serum vitamin A levels in umbilical vein and artery were positively correlated with birth weight.
关键词
新生儿 /
维生素 /
出生体重 /
脐带血 /
横断面研究
Key words
newborn /
birth weight /
umbilical cord /
vitamins /
cross sectional studies
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基金
国家重点研发计划（No.2017YFD0400600）
