目的 综述母乳维生素D水平,为婴儿补充维生素D提供参考。方法 系统检索CNKI、万方、维普、中国生物医学文献数据库、PubMed、Web of Science、Embase、Cochrane library中英文数据库,收集2022年4月之前公开发表的母乳维生素D水平的相关文献。将维生素D质量单位统一后,根据均数和标准差合并公式,计算国内外不同亚组母乳维生素D含量。结果 最终纳入14篇报告了足月分娩健康母亲母乳维生素D含量的原始文献,其中中国人群3篇,国外人群11篇。结果显示,中国足月分娩健康母亲初乳、过渡乳、成熟乳中维生素D含量（μg/L）分别为（0.801±0.342）、（25.132±30.540）、（3.792±0.614）。国外足月分娩健康母亲初乳、过渡乳、成熟乳中维生素D含量 (μg/L)分别为（25.191±15.845）、（1.045±1.740）、（0.943±2.034）。结论 国内外母乳维生素D水平差异较大,且受多种因素影响。未来需要更大样本量的研究,了解母乳维生素D含量及影响因素。
Abstract
Objective To assess the level of vitamin D in breast milk and provide evidence for vitamin D supplementation in the infants. Methods We searched for relevant studies published up to April 2022 from CNKI, Wanfang, VIP, CB-Mdisc, PubMed, Web of Science, Embase, and Cochrane library. After unifying the unit of vitamin D, we calculated the level of vitamin D in breast milk among the participants in different subgroups in China and abroad according to statistical formulas. Results A total of 14 articles were included in this study, including 3 articles performed in China and 11 articles performed in other countries. Our study showed that the levels of vitamin D in breast milk among Chinese healthy mothers with term infants in colostrum, transitional, and mature milk were (0.801±0.342) μg/L, (25.132±30.540) μg/L, and (3.792±0.614) μg/L, respectively. The levels of vitamin D in breast milk among foreign healthy mothers with term infants in colostrum, transitional, and mature milk were (25.191±15.845) μg/L, (1.045±1.740) μg/L, and (0.943±2.034) μg/L, respectively. Conclusion The level of vitamin D in breast milk in China was very different from that in other countries, which was influenced by numerous factors. Studies with larger sample sizes are needed to investigate the level of vitamin D in breast milk and its influencing factors.
关键词
母乳 /
维生素D /
水平 /
泌乳阶段
Key words
breast milk /
vitamin D /
level /
stage of lactation
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