原花青素,也叫缩合单宁,是天然来源的多酚化合物的代表物质,广泛存在于多种水果和蔬菜中。越来越多的证据表明,原花青素可以通过多种机制来预防帕金森病,已被用于帕金森病的实验性治疗中。但不同学者对于原花青素治疗帕金森病的作用效果的研究存在一定差异,因此在这项研究中,我们采用系统回顾的方法来全面评估原花青素在实验性帕金森病中的疗效。旨在探讨原花青素对机体的神经保护作用,为帕金森病的防治提供参考,为原花青素资源的开发利用提供科学依据。
Abstract
Proanthocyanidins, also called condensed tannins, are representative substances of polyphenolic compounds of natural origin and are widely found in a variety of fruits and vegetables. There is increasing evidence that proanthocyanidins can prevent Parkinson's disease through multiple mechanisms and have been used in experimental treatments of Parkinson's disease. However, there are some inconsistencies regarding the effects of proanthocyanidins on Parkinson's disease. In this study, we used a systematic appproach to comprehensively assess the efficacy of proanthocyanidins in experimental Parkinson's disease models. We aimed to investigate the neuroprotective effects of proanthocyanidins, to provide a reference for the prevention and treatment of Parkinson's disease, as well as a scientific basis for the development and utilization of proanthocyanidin resources.
关键词
PAC /
帕金森病 /
系统评价
Key words
proanthocyanidins /
Parkinson's disease /
systematic evaluation
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参考文献
[1] Reich SG, Savitt JM.Parkinson's disease[J]. Med Clin North Am,2019, 103:337–350.
[2] Global, regional,national burden of neurological disorders, 1990–2016:a systematic analysis for the Global Burden of DiseaseStudy 2016[J]. Lancet Neurol,2019, 18:459–480.
[3] Armstrong MJ, Okun MS.Diagnosis and treatment of Parkinson disease: a review[J]. JAMA. 2020, 323:548–560.
[4] Voon V, Napier TC, Frank MJ, et al. Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update[J]. Lancet Neurol,2017, 16:238–250.
[5] Izumi T, Terauchi M.The Diverse Efficacy of food-derived proanthocyanidins for middle-aged and elderly women[J]. Nutrients,2020, 12:123833.
[6] Aron PM, Kennedy JA.Flavan-3-ols: nature, occurrence and biological activity[J]. Mol Nutr Food Res,2008, 52: 79–104.
[7] Di Lorenzo C, Colombo F, Biella S, et al. Polyphenols and human health :the role of bioavailability[J]. Nutrients,2021, 13:010273.
[8] Ardid-Ruiz A, Harazin A, Barna L, et al. The effects of Vitis vinifera L. phenolic compounds on a blood-brain barrier culture model: Expression of leptin receptors and protection against cytokine-induced damage[J]. J Ethnopharmacol. 2020, 247:112253.
[9] Moreira ELG, Rial D, Aguiar AS, et al. Proanthocyanidin- rich fraction from Croton celtidifolius Baill confers neuroprotection in the intranasal 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine rat model of Parkinson’s disease[J]. J Neural Transmission,2010,117:1337–1351.
[10] 刘国安,吴亚楠,董欢,等. PAC对鱼藤酮诱导PC12细胞损伤的保护作用及机制研究[J]. 西北师范大学学报(自然科学版), 2018, 54:57–64.
[11] 梁春波,张舫. PAC对帕金森模型小鼠黑质氧化应激损伤影响[J]. 临床军医杂志,2016, 44:1172–1174.
[12] 陈金枝. PAC抑制小胶质细胞活化及其对鱼藤酮诱导多巴胺能神经元损伤的保护作用[D]. 南京:东南大学, 2016:14–33.
[13] 张妍. PAC抑制小胶质细胞活化及保护SH-SY5Y神经细胞的机制研究[D]. 南京:东南大学, 2018:7–25.
[14] 卢晓星. PAC抑制LPS/ATP诱导小胶质细胞NLRP3炎症小体激活及对SH-SY5Y细胞损伤的保护作用[D]. 南京:东南大学, 2020:15–39.
[15] Xu YL, Xu Y, Li HF, et al. Improvement effect of proanthocyanidins on cell viability of rotenone-induced Parkinson's disease model[J]. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2020, 36:424–427.
[16] Chen J, Chen Y, Zheng Y, et al. Protective effects and mechanisms of procyanidins on Parkinson's disease in vivo and in vitro[J]. Molecules,2021, 26:185558.
[17] Xu Q, Chen Z, Zhu B, et al. Neuroprotective effects of β-type cinnamon procyanidin oligomers on MPP(+)- induced apoptosis in a cell culture model of Parkinson's disease[J]. Molecules,2021, 26:216422
[18] Chen H, Xu J, Lv Y, et al.Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP-induced Parkinson's disease models in vitro and in vivo[J]. Mol Med Rep,2018, 18:4913–4921.
[19] Ma J, Gao SS, Yang HJ, et al. Neuroprotective effects of proanthocyanidins, natural flavonoids derived from plants, on rotenone-induced oxidative stress and apoptotic cell death in human neuroblastoma SH-SY5Y Cells[J]. Front Neurosci,2018, 12:369.
[20] Fracassetti D, Costa C, Moulay L, et al. Ellagic acid derivatives, ellagitannins, proanthocyanidins and other phenolics, vitamin C and antioxidant capacity of two powder products from camu-camu fruit (Myrciaria dubia)[J]. Food Chem, 2013, 139:578–588.
[21] Lev N, Melamed E, Offen D.Apoptosis and Parkinson's disease[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2003, 27:245–250.
[22] Wang J, Yu T, Sheng L, et al. Lotus seedpod proanthoc- yanidins protect against light-induced retinal damage via antioxidative stress, anti-apoptosis, and neuropro- tective effects[J]. Med Sci Monit, 2021, 27:e935000.
[23] Pajares M, IRA, Manda G, et al. Inflammation in Parkinson's disease:mechanisms and therapeutic implications[J]. Cells,2020, 9:071687.
基金
中央高校基本科研业务费专项资金资助和江苏省普通高校研究生科研创新计划资助项目（No. SJZZ16_0034）
