目的 探讨老年人群中膳食白藜芦醇（RES）摄入与肌少症之间的关联。方法 本研究数据来源于天津市慢性低度炎症与健康（TCLSIH）队列研究。肌少症根据亚洲肌少症工作组推荐的共识诊断;膳食中RES摄入量采用食物频率问卷进行评估;采用Logistic回归模型分析RES摄入量与肌少症患病率之间的关联。结果 共纳入3643名60岁及以上老年人,男性1640人,女性2003人,在总人群中548人检查出肌少症,患病率为15.0%,老年男性有311人（患病率为19.0%）,老年女性有237人（患病率为11.8%）;在对潜在混杂因素进行调整后,总人群不同组别RES摄入量与肌少症患病率之间的OR值（95%置信区间)分别是：1.00 (参考值)、0.81 (0.60, 1.10)、0.79 (0.59, 1.07)和0.55 (0.40, 0.77),P<0.001,在老年男性中分别为1.00 (参考值)、0.81 (0.53, 1.25)、0.61 (0.40, 0.93)和0.47 (0.29, 0.76),P<0.001,老年女性中分别为1.00 (参考值)、0.88 (0.57, 1.38)、1.15 (0.74, 1.80)和0.74 (0.46, 1.20),P = 0.47。结论 在60岁及以上的老年人群中RES摄入量与肌少症呈负相关,这种关联在老年男性人群中存在显著性,但在老年女性人群中无显著性。
Abstract
Objective To investigate the association between daily dietary intake of resveratrol (RES) and sarcopenia in elderly adults. Methods Data were collected from Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort study. The diagnostic criteria for sarcopenia were primarily based on the consensus recommended by the Asian Working Group for Sarcopenia Syndrome (AWGS). RES intake was assessed using a food frequency questionnaire (FFQ). Logistic regression model was used to analyze the association between RES intake and sarcopenia. Results This study included a total of 3643 participants aged 60 and above, including 1640 males and 2003 females. The prevalence of sarcopenia in the general population was 15.0%, including 19.0% in male and 11.8% in female. After adjusting for confounding variables, the OR and 95% CI of prevalence rate of sarcopenia by RES intake groups were 1.00 (reference), 0.81 (0.60, 1.10), 0.79 (0.59, 1.07), and 0.55 (0.40, 0.77) (P for trend <0.001). When stratified by sex, the OR and 95% CI in male were 1.00 (reference), 0.81 (0.53, 1.25), 0.61 (0.40, 0.93), and 0.47 (0.29, 0.76) (P for trend <0.001). The OR and 95% CI in female were 1.00 (reference), 0.88 (0.57, 1.38), 1.15 (0.74, 1.80), and 0.74 (0.46, 1.20) (P for trend = 0.47). Conclusion In the elderly population, dietary intake of RES is negatively associated with sarcopenia. The association is significant in male, but not in female.
关键词
白藜芦醇 /
肌少症 /
老年人 /
横断面研究
Key words
resveratrol /
sarcopenia /
elderly /
cross-sectional study
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基金
国家自然科学基金面上项目（No.82373562）
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