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中国应用生理学杂志 ›› 2016, Vol. 32 ›› Issue (2): 185-190.doi: 10.13459/j.cnki.cjap.2016.02.024

• 研究论文 • 上一篇    下一篇

在生理学研究中要正确运用统计学

沈宁, 刘一松, 郭春雪, 胡完, 杨孟渊, 胡良平   

  1. 军事医学科学院生物医学统计学咨询中心, 北京 100850
  • 收稿日期:2015-06-15 修回日期:2015-10-12 出版日期:2016-03-28 发布日期:2018-06-12
  • 通讯作者: 胡良平,Tel:010-66932127;E-mail:lphu812@sina.com E-mail:lphu812@sina.com
  • 基金资助:
    胡良平,Tel:010-66932127;E-mail:lphu812@sina.com

Appropriate application of statistical methods in physiological research

SHEN Ning, LIU Yi-song, GUO Chun-xue, HU Wan, YANG Meng-yuan, HU Liang-ping   

  1. Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2015-06-15 Revised:2015-10-12 Online:2016-03-28 Published:2018-06-12
  • Contact: 胡良平,Tel:010-66932127;E-mail:lphu812@sina.com E-mail:lphu812@sina.com
  • Supported by:
    胡良平,Tel:010-66932127;E-mail:lphu812@sina.com

摘要: 目的:为从事生理学研究的科研工作者正确运用统计学提供一些有效的技术方法。方法:通过全面系统地阐述"统计学在生理学研究过程中充当了重要的角色"和"使生理学研究课题得出的结论经得起时间和实践检验的关键技术"两个命题,突显出统计学对于科研工作的重要性、解释了统计学难学难用的原因,并提供了正确运用统计学的关键技术。结果:呈现出统计学的三大核心内容,即"如何使课题设计无可挑剔"、"如何严守课题实施的操作规程"和"如何使结论陈述有理有据",使正确运用统计学具有很强的可操作性。结论:在生理学研究中,只要锲而不舍地追求科学严谨的科研作风和精湛的科研技能,就一定能使所获得的科研结论经得起时间和实践的检验。

关键词: 生理学, 统计学, 科研设计, 质量控制, 数据管理, 统计分析

Abstract: Objective: To offer a series of efficient methods to physiologists in appropriate selection, and application of statistical techniques. Methods: We bring about two questions as follows:What's the role of statistics in the process of a physiological research? How to make sure the results produced in a physiological research can be repeatable in practice in the long run. From the answers to these two questions, we highlight the importance of the discipline of statistics to research work, explain why it is difficult, how to choose a suitable statistical method in a specific situation, and offer the critical methods to use statistics accurately and appropriately. Results: We abstract three core sections from the discipline of statistics:how to make the design of a study impeccable; How to strictly follow the protocol of a study, and How to draw conclusions well reasoned and strongly supported by evidence. By elaborating these sections, it is feasible to correctly use statistical methods for data analysis and results interpretation. Conclusion: In physiological research, conclusion can stand with time and repeatable in practice only when researchers strictly and rigorously follow the rule of scientific research.

Key words: physiology, statistics, study design, quality control, data management, statistical analysis

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