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中国应用生理学杂志 ›› 2019, Vol. 35 ›› Issue (6): 548-550.doi: 10.12047/j.cjap.5879.2019.120

• 研究论文 • 上一篇    下一篇

阿奇霉素对阿霉素与白蛋白致小鼠肾损害的保护作用*

唐逸豪1, 殷成哲2, 李凯3, 李伟鑫4, 范春芳1△   

  1. 1. 中国人民武警特色医学中心药剂科, 天津 300162;
    2. 武警天津市总队执勤第一支队勤务保障大队卫生队药师, 天津 300202;
    3. 江苏总队镇江支队勤务保障大队卫生队军医, 镇江 212000;
    4. 武警后勤学院, 天津 300300
  • 收稿日期:2019-05-13 出版日期:2019-11-28 发布日期:2020-04-02
  • 通讯作者: 天津市救援医学临床医学研究中心(15ZXLCSY00040)

Protective effects of azithromycin on adriamycin-induced nephropathy with albumin overload in mice

TANG Yi-hao1, YIN Cheng-zhe2, LI Kai3, LI Wei-xin4, FAN Chun-fang1△   

  1. 1. Department of Pharmacy, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162;
    2. Pharmacist, Health Team, Service Support Group, No.1 Detachment, Tianjin Armed Police Corps, Tianjin 300202;
    3. Military Doctor of Health Team of Zhenjiang Branch Service Support Brigade, Jiangsu Corps, Zhenjiang 212000;
    4. Logistics College of Chinese People's Armed Police Force, Tianjin 300300, China
  • Received:2019-05-13 Online:2019-11-28 Published:2020-04-02

摘要: 目的:研究阿奇霉素对阿霉素与白蛋白致小鼠肾损害的肾脏保护作用。方法:取BALB/c雄性小鼠40只,按照随机数表法平均分为空白对照组(Ctrl组)、肾损害模型组(ADR+BSA组)、阿奇霉素治疗组(Azm组)及醋酸泼尼松阳性对照组(Pdn组);ADR+BSA、AZM及Pdn三组每周5 d尾静脉注射9.8 mg·kg-1阿霉素,腹腔注射10 mg·kg-1血清白蛋白,对照组注射生理盐水,持续4周造模;之后,AZM组每天给予62.5 mg·kg-1阿奇霉素灌胃,Pdn组每天给予12.5 mg·kg-1醋酸泼尼松灌胃,其余两组给予等量生理盐水,持续6周后,收集并记录24 h尿量,检测尿蛋白量、内生肌酐清除率,取血检测血清生化指标和免疫因子。结果:与Ctrl组相比,ADR+BSA组小鼠24 h尿蛋白定量显著升高(P<0.05),Ccr显著降低(P<0.05);经过阿奇霉素治疗后的小鼠,24 h蛋白定量相比于ADR+BSA组显著降低(P<0.05),Ccr显著升高(P<0.05)。结论:阿奇霉素对阿霉素与白蛋白致小鼠的肾损害有一定的保护作用。

关键词: 阿奇霉素, 白蛋白过载, 阿霉素, 肾脏保护, 小鼠

Abstract: Objective: To study the protective effects of azithromycin on renal damage induced by doxorubicin and albumin in mice. Methods: Forty male BALB/c mice were randomly divided into blank control group (Ctrl group), renal damage model group (ADR+BSA group), azithromycin treated group (Azm group) and prednisone acetate positive control group (Pdn group) in accordance with random number table method. Mice in ADR+BSA, AZM and Pdn group were injected intravenously with 9.8 mg·kg-1 doxorubicin five days a week, 10 mg·kg-1 serum albumin was injected intraperitoneally, and normal saline was administered to the control group for 4 weeks to establish renal damage model. After that, AZM group was given daily. 62.5 mg·kg-1 azithromycin was intragastrically administered. The Pdn group was given 12.5 mg·kg-1 prednisone acetate daily, the other two groups were given the same amount of normal saline. After 6 weeks, the urine volume was collected and recorded for 24 hours to detected urine protein amount and endogenous creatinine clearance rate (Ccr). Serum biochemical indicators and serum immune factors were detected. Results: Compared with the Ctrl group, the 24 h urine protein level of the ADR+BSA group was increased significantly (P<0.05), and the Ccr was decreased significantly (P<0.05). After the azithromycin treatment, the 24 h urine protein was decreased significantly (P<0.05), while the Ccr was increased significantly (P<0.05) compared with ADR+BSA group. Conclusion: Azithromycin has a protective effects on the renal damage induced by doxorubicin and albumin in mice.

Key words: azithromycin, albumin overload, adriamycin, renal protection, mice

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