Preliminary report on partial pressure changes of oxygen and carbon dioxide in umbilical artery and vein before and after the first breath in Chinese neonates II—The personalized analysis of partial pressure of oxygen and carbon dioxide difference between umbilical artery and vein at same time in same newborn

doi:10.12047/j.cjap.0100.2021.099

Abstract

Abstract: Objective: In order to explore the mechanism of neonatal spontaneous breathing, the difference of oxygen and carbon dioxide between umbilical cord arteries and veins before the start of spontaneous breathing after birth has been analyzed among people. In this part, the related information is analyzed individually. Methods: After all fetal parents signed the informed consent before birth, and before the newborn was born and did not breathe, the umbilical cord was exposed as quickly as possible, and the heparinized arterial indwelling needle was inserted into the umbilical artery and umbilical vein in the direction of newborn and placenta, and then blood was taken continuously. Although dozens of mothers were selected,but only 3 cases were collected from Pua and Puv blood samplers at the same time for blood gas analysis and determination, and the differences and dynamic changes of umbilical vein and umbilical artery were calculated and analyzed. Results: In all 3 none spontaneous breathing newborns,PuvO₂ was significantly higher than PuaO₂ at the same time (P<0.01), with an average difference of (24.17±7.09) mmHg; while PuvCO₂was significantly lower than PuaCO₂ (all P<0.01), with an average difference of (-7.67±3.70) mmHg.The difference of Puv-uaO₂ was significantly higher than those of Puv-uaCO₂ (P<0.05). Conclusion: PuaO₂decreases gradually with time (heartbeat frequency) before spontaneous breathing after the delivered fetus as a newborn, and it induces the first inhalation to start spontaneous breathing when it reaches the threshold of triggering breathing.

Key words: newborn after birth before breathing, umbilical artery and umbilical vein take blood continuously, blood gas analysis, umbilical arterial oxygen partial pressure, respiratory regulation control signal

CLC Number:

R332

LIU Fang, SUN Xing-guo, LI Qi-wei, GE Wan-gang, LI Hao, LIU Yan-ling, CI Zheng, CHEN Sheng-ping, SONG Gui-qin, WANG Gui-zhi, TAN Xiao-yue, CUI Yan, ZHANG Ye, ZHU Jia-bao, LI Yin-jun, DENG Wei, HUANG Yan, MA Ming-xin, CHEN Rong, ZOU Yu-xin, TAI Wen-qi, XU Fan, SHI Chao. Preliminary report on partial pressure changes of oxygen and carbon dioxide in umbilical artery and vein before and after the first breath in Chinese neonates II—The personalized analysis of partial pressure of oxygen and carbon dioxide difference between umbilical artery and vein at same time in same newborn[J]. CJAP, 2021, 37(1): 9-14.

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