瑞舒伐他汀联合普罗布考对女性绝经后高血压合并高血脂患者内皮功能的影响

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摘要目的观察瑞舒伐他汀联合普罗布考对女性绝经后高血压合并高血脂患者血管内皮功能的影响及长期联合治疗的临床意义。方法 84例患者随机分为他汀组(瑞舒伐他汀10 mg/d,n=42)与联合治疗组(瑞舒伐他汀10 mg/d+普罗布考500 mg/d,n=42),治疗前和治疗后3个月、6个月、1年、2年后分别检测患者血清血脂、血糖、肝肾功能,并于相同时间点应用高频超声测肱动脉血流介导的内皮依赖血管舒张功能(FMD)和硝酸甘油诱导的内皮非依赖血管舒张功能(NMD)。结果经治疗3个月后两组血清总胆固醇、低密度脂蛋白均明显低于治疗前(P＜0.01),联合治疗组下降更明显(P＜0.05),随着治疗时间延长进一步降低,至6个月时达到相对稳定状态,治疗后2年与治疗后1年比较无明显差异(P＞0.05)。治疗后3个月,FMD均明显高于治疗前,两组比较差异有统计学意义(P＜0.05),2年后两组FMD高于治疗1年后,联合治疗组明显高于他汀组,两组比较差异明显(P＜0.01)。两组NMD在治疗1年及2年后均明显高于治疗前。结论长期瑞舒伐他汀联合普罗布考治疗较单用瑞舒伐他汀能更明显改善女性绝经后高血压合并高血脂患者的内皮功能。

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关键词 ：降脂药物, 内皮功能, 高血压合并高血脂, 绝经后妇女

Abstract：Objective To evaluate the effects of rosuvastatin combined with probucol on endothelial function in patients with hypertension and hyperlipemia.Methods A total of 84 postmenopausal patients with hypertension and hyperlipemia were randomly divided into rosuvastatin (10 mg/d) group (n=42) and rosuvastatin (10 mg/d) combined with probucol (500 mg/d) group (n=42).Serum lipids, glucose, liver and kidney function, endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent sublingual nitroglycerin-mediated dilatation(NMD) were detected before therapy and 3 months, 6 moths,1 years and 2 years after therapy.Results Compared to baseline value, the levels of total cholesterol and LDL-C decreased significantly 3 months after therapy in both groups (P<0.01), especially in combination group; The levels of these two parameters decreased with therapy time, and reached a steady state after 6 months therapy; There was no significant deference about the levels of these two parameters between 1 year after therapy and 2 years after therapy. FMD levels in 3 months after therapy and 2 years after therapy increased significantly compared to before therapy and 1 year after therapy, respectively in both groups (P<0.01), and FMD was significantly higher in rosuvastatin combined with probucol group than rosuvastatin group (P<0.01). NMD levels in 1 year after therapy and 2 years after therapy also increased significantly compared to before therapy in two groups but there was no statistical difference between two groups.Conclusion The rosuvastatin combined with probucol therapy was superior to rosuvastatin alone on improving endothelial function of postmenopausal patients with hypertension and hyperlipemia.

Key words： antilipemic agents endothelial function postmenopausal patients hypertension and hyperlipemia

出版日期: 2016-08-30

引用本文:

董均杰, 杨静茹, 范瑞云. 瑞舒伐他汀联合普罗布考对女性绝经后高血压合并高血脂患者内皮功能的影响[J]. 解放军预防医学杂志, 2016, 34(3): 385-388.
DONG Junjie, YANG Jingru, FAN Ruiyun. Effects of Rosuvastatin Combined with Probucol on Endothelial Function in Postmenopausal Patients with Hypertension and Hyperlipemia. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(3): 385-388.

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/ 或 http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/Y2016/V34/I3/385

〔1〕 TZIOMALCS K,KAKMQKA A I,ATHYROE VC,el al.The role of statins for the primry and secondary prevention ofcoronary heart disease in women〔J〕.Curt Pharm Des,2009,15:1054.
〔2〕 TAGAWA T,URABE Y,KIMURA Y,el al.Long-term treatment with probucol improves endothelial function in patients with coronary artery disease〔J〕.Hypertens Res,2004,27:311.
〔3〕 YOKOYAMA T,MIYAUCHI K,KURATA T,el al.Effect probucol on neointimal thickening in astent porcine restenosis model〔J〕.Jpn Heart J,2004,45(2):305.
〔4〕徐盛开,伏静媛,宁金民,等.阿托伐他汀对高血压患者血管内皮功能的影响〔J〕.高血压杂志,2005,13:403.
〔5〕 GEMEZ.DOBLAS J J,JIMENEZ—NAVARRO M F,GARCFA-PINILLA J M,el al.Effect of statin treatment begun early after acute myocardial infarction on endothelial funetion in patients with normal levels of cholesterol VAATOPE study (VAlue of ATOrvastatin in Postinfarction Endothelium) 〔J〕.Med Clin(Barc),2006,126:325.
〔6〕 DUPUIS J,TARDIFJ C,ROULEAU J L,el al.Intensity oflipid lowering with statins and brachial artery vascular endothelium reactivity after acute coronary syndromes(from the BRAVER trial) 〔J〕.Am J Cardiol,2005,96:1207.
〔7〕 MATURANA M A,LRIGOYEN M C,SPRITZER P M.Menopause,estrogens and endothelial dysfunction:current concepts〔J〕.Clinics,2007,62(1):77.
〔8〕董红梅,黄岚,宋耀明,等.急性冠状动脉综合征患者血浆氧化型低密度脂蛋白、高敏C反应蛋白与血管内皮损伤的关系〔J〕.中国动脉硬化杂志,2006,14(3):227.
〔9〕农盛雄,罗石坚,郭茹,等.阿托伐他汀联合阿仑膦酸钠治疗动脉粥样硬化疗效观察〔J〕.中外医疗,2013,32(28):12.
〔10〕刘和兰.高血压合并高血脂治疗药物的分析及安全性分析〔J〕.北方药学,2014(2):130.
〔11〕张志杰,张志瑛,吴京兰,等.辛伐他汀改善高血压合并高血脂患者的血管内皮功能〔J〕.临床和实验医学杂志,2008,7(8):29.
〔12〕翁春艳,唐晓鸿,袁洪,等.高血压合并高脂血症对血管早期病变的影响〔J〕.中国动脉硬化杂志, 2012,20(1):52.
〔13〕叶毅敏,叶志荣.辛伐他汀对高血压患者合并高血脂症的血管内皮功能改善与血胆固醇降低程度不相关〔J〕.中华高血压杂志,2008,16(8):728.
〔14〕吴伟军,郑贤干,吴胜利.辛伐他汀对高血压合并高血脂患者血管内皮功能的干预作用〔J〕.中国药房,2011,22(44):4173.
〔15〕匡永东,吕良东,龚明.瑞舒伐他汀对高血压合并高脂血症患者血压的影响〔J〕.中国药业,2012,21(7):47.
〔16〕朱岩岩,李彤,李合华,等.高血压合并高血脂建立脑动脉粥样硬化大鼠模型的实验研究〔J〕.中华脑科疾病与康复杂志:电子版,2014(2):31.
〔17〕 WAQAR A B, KOIKE T, YU Y,el al.High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits〔J〕.Atherosclerosis,2010,213(1):148.
〔18〕李云飞,孙艳霞.阿托伐他汀对老年高血压合并高脂血症患者血压的影响〔J〕.中华老年心脑血管病杂志,2014(8):869.
〔19〕陈善,周晓秋,叶梁,等.辛伐他汀对轻中度高血压合并高血脂症患者血清炎症介质、血小板活化功能和血液流变学的影响〔J〕.中华高血压杂志,2015(5):477.
〔20〕王彦君,张超群,毛宇光.阿托伐他汀治疗高血压合并高血脂的疗效及其对内皮功能的影响〔J〕.临床合理用药杂志,2015(26):43.　　

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