Abstract：Objective To investigate the correlation of IGF-2 and IGFBP-2 with invasive ability in patients with liver cancer.Methods 124 cases of liver cancer patients were divided into stage I、II、III、IV.There were 29、31、36、28 patients in each stage separately. Levels of IGF-2, IGFBP -2, MMP-2 and TIMP-2 in the serum of patientswere detected.Results Levels of IGF-2 and IGFBP-2 in stage II patients were significantly higher (P<0.05)than in stage I. Levels of IGF-2 and IGFBP-2 were significantly higher in stage III than in stage I and II(P<0.05). Levels of IGF-2 and w IGFBP-2 were significantly different(P<0.05)from those in stageⅠ, Ⅱ, and Ⅲ. Levels of MMP-2 / TIMP-2 were significantly higher (P<0.05)in stage II than in stage I,while levels of MMP-2 and TIMP-2 in stage Ⅲ were significantly different(P<0.05)from those in stage I. Levels of MMP-2, TIMP-2 and MMP-2 / TIMP-2 were significantly different from those in stageⅠ , Ⅱ, and Ⅲ (P<0.05). IGF-2, TIMP-2, and MMP-2 / TIMP-2 were significantly correlated (P<0.05), so were IGFBP-2, TIMP-2, and MMP-2 / TIMP-2 (P<0.05).Conclusion With the progress of liver cancer, IGF-2 and IGFBP-2 levels are closely related to ECM remodelling ability , which is an important factor to reflect the invasive ability of cancer cells.
陈 炜. 不同分期肝癌患者血清IGF-2及IGFBP-2水平与肝癌侵袭能力的相关性分析[J]. 解放军预防医学杂志, 2016, 34(6): 866-868.
CHEN Wei. Correlation Analysis of Igf-2 And Igfbp-2 with Invasive Ability in Patients with Liver Cancer. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(6): 866-868.
GERSHTEIN E,KUSHLINSKII N.Clinical prospects of IGF-signaling system components study in ovarian cancer patients[J].Drug Metabol Personal Ther,2015,30(2):75.
[3]
SLIFIERZ M J,FRIENDSHIP R,DE LANGE C F,et al.Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs[J].Animal,2014,8(5):844.
[4]
LAI J P,CONLEY A,KNUDSEN B S,et al.Hypoxia after transarterial chemoembolization (TACE) may trigger a progenitor cell phenotype in hepatocellular carcinoma (HCC)[M].Histopathology.2014.
[5]
LI Y P,NIU A,WEN Y.Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFalpha release[J].Front Cell Dev Biol,2014,2:21.
[6]
LEVI J,HUYNH F K,DENROCHE H C,et al.Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice[J].Diabetologia,2012,55(3):752.
[7]
LEWITT M S.Effect of Ghrelin on Hepatic IGF-Binding Protein-1 Production[J].ISRN Obes,2013,2013:751401.
[8]
SIRBU A,GOLOGAN S,ARBANAS T,et al.Adiponectin, body mass index and hepatic steatosis are independently associated with IGF-I status in obese non-diabetic women[J].Growth Horm IGF Res,2013,23(1-2):2.
[9]
DONG Z,XU X,DU L,et al.Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion[J].Carcinogenesis,2013,34(5):974.
[10]
ZINEVICH L S,GONCHAROVA N O,URUVAEVA I V,et al.Igf-1 and its isoform expression in hepatic cell tumors and the surrounding tissue in mice liver carcinogenesis induced by diethylnitrozamine[J]. Izv Akad Nauk Ser Biol,2013(6):673.
[11]
FU Q,MCKNIGHT R A,CALLAWAY C W,et al.Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene[J].FASEB J,2014,17(2):134.
[12]
HVID H,BLOUIN M J,BIRMAN E,et al.Treatment with insulin analog X10 and IGF-1 increases growth of colon cancer allografts[J].PLoS One,2013,8(11): e79710.
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