A SYSTEMATIC REVIEW ON LONGITUDINAL CHANGES OF PROTEIN CONTENT IN BREAST MILK IN DIFFERENT LACTATION PERIODS
WANG Yi-ran1, MU Qi-er1, LI Cheng1, LUO Yuan-li2, ZHANG Ya-di3, LAI Jian-qiang4,5,6, YANG Yue-xin4,5, ZHU Jing4,7
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1Beijing Institute of Nutritional Resources Co.,Ltd.,Beijing 100069; 2West China School of Public Health, Sichuan University, Chengdu 610041; 3Capital Medical University , Beijing 100069; 4China-DRIs Research Group on Human Milk Composition, Beijing 100050; 5National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050; 6Key Laboratory of Human Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050; 7Institute of Biotechnology and Health, Beijing Academy of Science and Technology, Beijing 100089, China
Objective To systematically review the changes of total protein levels in different lactation periods and special cases in breast milk, and provide data support for exploring Chinese infants’ protein requirements. Methods Systematic retrieval of literatures were performed from 5 English databases and 3 Chinese databases. The data was filtering by the inclusion and exclusion criteria, and data extraction and merging were conducted by lactational periods when the same experimental methods were used for determining the total protein content in breast milk. Results A total of 62 English articles and 16 Chinese articles were included, in which 15 articles of Chinese term milk samples, 51 articles of foreign term milk samples, 2 articles of Chinese preterm milk samples and 10 articles of foreign preterm milk samples were collected. In total, 1816 Chinese milk samples and 6002 foreign milk samples were used for data merging. The protein levels in Chinese milk samples and foreign milk samples were gradually decreased throughout lactation stages. Conclusion The mean and standard deviation of protein levels of term and preterm breast milk in different lactational periods were calculated, Which contribute to study on infants’ protein requirements in China.
WANG Yi-ran, MU Qi-er, LI Cheng, LUO Yuan-li, ZHANG Ya-di, LAI Jian-qiang, YANG Yue-xin, ZHU Jing.
A SYSTEMATIC REVIEW ON LONGITUDINAL CHANGES OF PROTEIN CONTENT IN BREAST MILK IN DIFFERENT LACTATION PERIODS[J]. Acta Nutrimenta Sinica. 2024, 46(1): 86-94
中图分类号：
R153.1
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参考文献
[1] Donovan SM.Human milk proteins: composition and physiological significance[J]. Nestle Nutr Inst Workshop Ser, 2019, 90:93–101. [2] Ballard O,Morrow A L.Human milk composition: nutrients and bioactive factors[J]. Pediatr Clin North Am, 2013, 60:49–74. [3] Lönnerdal B.Nutritional and physiologic significance of human milk proteins[J]. Am J Clin Nutr, 2003, 77:1537S–1543S. [4] Zhang Q,Cundiff JK,Maria SD, et al.Quantitative analysis of the human milk whey proteome reveals developing milk and mammary-gland functions across the first year of lactation[J]. Proteomes, 2013, 1:128–158. [5] Liu B, Gu FJ, Ye WH,et al. Colostral and mature breast milk protein compositional determinants in Qingdao, Wuhan and Hohhot:maternal food culture, vaginal delivery and neonatal gender[J]. Asia Pac J Clin Nutr, 2019, 28:800–811. [6] Dawodu AH,Osibanjo O,Damole ID.Nutritional composition and volume of milk produced by mothers of preterm infants in developing countries[J]. J Trop Pediatr, 1989, 35:95–96. [7] Agostoni C, Carratù B, Boniglia C,et al. Free glutamine and glutamic acid increase in human milk through a three-month lactation period[J]. J Pediatr Gastroenterol Nutr, 2000, 31:508–512. [8] Agostoni C, Carratù B, Boniglia C,et al. Free amino acid content in standard infant formulas: comparison with human milk[J]. J Am Coll Nutr, 2000, 19:434–438. [9] Anderson DM, Williams FH, Merkatz RB,et al. Length of gestation and nutritional composition of human milk[J]. Am J Clin Nutr, 1983, 37:810–814. [10] Arnold J, Leslie G, Chen S.Protein, lactose and fat concentration of breast milk of mothers of term and premature neonates[J]. Aust Paediatr J, 1987, 23:299–300. [11] Atkinson SA,Bryan MH,Anderson GH.Human milk: difference in nitrogen concentration in milk from mothers of term and premature infants[J]. J Pediatr, 1978, 93:67–69. [12] Aumeistere L,Ciproviča I,Zavadska D,et al. Impact of maternal diet on human milk composition among lactating women in latvia[J]. Medicina (Kaunas), 2019, 55:173. [13] Barbosa L, Butte NF,Villalpando S,et al. Maternal energy balance and lactation performance of Mesoamerin- dians as a function of body mass index[J]. Am J Clin Nutr, 1997, 66:575–583. [14] Boediman D, Ismail D, Iman S,et al. Composition of breast milk beyond one year[J]. J Trop Pediatr Environ Child Health, 1979, 25:107–110. [15] Boniglia C,Carratù B,Chiarotti F,et al. Influence of maternal protein intake on nitrogen fractions of human milk[J]. Int J Vitam Nutr Res, 2003, 73:447–452. [16] Brown KH, Black RE, Robertson AD,et al. Clinical and field studies of human lactation:methodological considerations[J]. Am J Clin Nutr, 1982, 35:745–756. [17] Butte NF, Calloway DH.Evaluation of lactational performance of Navajo women[J]. Am J Clin Nutr, 1981, 34:2210–2215. [18] Butte NF, Garza C, Johnson CA,et al. Longitudinal changes in milk composition of mothers delivering preterm and term infants[J]. Early Hum Dev, 1984, 9: 153–162. [19] Butte NF, Garza C, Smith EO,et al. Human milk intake and growth in exclusively breast-fed infants[J]. J Pediatr, 1984, 104:187–195. [20] Butte NF, Villalpando S, Wong WW,et al. Human milk intake and growth faltering of rural Mesoamerindian infants[J]. Am J Clin Nutr, 1992, 55:1109–1116. [21] Butte NF,Wong WW,Ferlic L,et al. Energy expenditure and deposition of breast-fed and formula-fed infants during early infancy[J]. Pediatr Res, 1990, 28: 631–640. [22] Carratù B,Boniglia C,Scalise F,et al. Nitrogenous components of human milk:non-protein nitrogen, true protein and free amino acids[J]. Food Chem, 2003, 81: 357–362. [23] Darragh AJ,Moughan PJ.The amino acid composition of human milk corrected for amino acid digestibility[J]. Br J Nutr, 1998, 80:25–34. [24] Darwish AEL M, Dakroury AM, El-Feel MS,et al. Comparative study on breast milk of mothers delivering preterm and term infants--protein, fat and lactose[J]. Nahrung, 1989, 33:249–251. [25] Davis TA, Nguyen HV, Garcia-Bravo R,et al. Amino acid composition of the milk of some mammalian species changes with stage of lactation[J]. Br J Nutr, 1994, 72:845–853. [26] De Bruin NC, Degenhart HJ, Gal S, et al. Energy utiliza- tion and growth in breast-fed and formula-fed infants measured prospectively during the first year of life[J]. Am J Clin Nutr, 1998, 67:885–896. [27] Dewey KG, Lovelady CA, Nommsen-Rivers LA,et al. A randomized study of the effects of aerobic exercise by lactating women on breast-milk volume and composition[J]. N Engl J Med, 1994, 330:449-453. [28] Donovan SM, Lonnerdal B.Non-protein nitrogen and true protein in infant formulas[J]. Acta Paediatr Scand, 1989, 78:497–504. [29] Donovan SM, Lonnerdal B.Isolation of the nonprotein nitrogen fraction from human milk by gel-filtration chromatography and its separation by fast protein liquid chromatography[J]. Am J Clin Nutr, 1989, 50:53–57. [30] Ferlin ML, Santoro JR, Jorge SM,et al. Total nitrogen and electrolyte levels in colostrum and transition human milk[J]. J Perinat Med, 1986, 14:251–257. [31] Garza C, Johnson CA, Smith EO,et al. Changes in the nutrient composition of human milk during gradual weaning[J]. Am J Clin Nutr, 1983, 37:61–65. [32] Greer FR, McCormick A. Improved bone mineralization and growth in premature infants fed fortified own mother's milk[J].J Pediatr,1988,112:961–969. [33] Gross SJ, David RJ, Bauman L, et al. Nutritional composition of milk produced by mothers delivering preterm[J]. J Pediatr, 1980, 96:641–644. [34] Hopkinson JM, Schanler RJ, Fraley JK, et al. Milk production by mothers of premature infants: influence of cigarette smoking[J]. Pediatrics, 1992,90:934–938. [35] Hosoi S, Honma K, Daimatsu T,et al. Lower energy content of human milk than calculated using conversion factors[J]. Pediatr Int, 2005, 47:7–9. [36] Khin Maung N,Tin TO,Kywe-Thein MS,et al. Study on lactation performance of Burmese mothers[J]. Am J Clin Nutr, 1980, 33:2665–2668. [37] Kreissl A, Valentina Z,Repa A,et al. Human milk analyser shows that the lactation period affects protein levels in preterm breastmilk[J]. Acta Paediatr, 2016, 105:635–640. [38] Kunz C, Lönnerdal B.Re-evaluation of the whey protein/casein ratio of human milk[J]. Acta Paediatr, 1992, 81:107–112. [39] Lammi-Keefe CJ, Ferris AM, Jensen RG.Changes in human milk at 0600, 1000, 1400, 1800, and 2200 h[J]. J Pediatr Gastroenterol Nutr, 1990, 11:83–88. [40] Lemons JA, Moye L,Hall D,et al. Differences in the composition of preterm and term human milk during early lactation[J]. Pediatr Res, 1982, 16:113–117. [41] Lonnerdal B,Forsum E.Casein content of human milk[J]. Am J Clin Nutr, 1985, 41:113–120. [42] Lonnerdal B,Forsum E,Gebre-Medhin M,et al. Breast milk composition in Ethiopian and Swedish mothers. II. Lactose, nitrogen, and protein contents[J]. Am J Clin Nutr, 1976, 29:1134–1141. [43] Lonnerdal B, Forsum E, Hambraeus L.A longitudinal study of the protein, nitrogen, and lactose contents of human milk from Swedish well-nourished mothers[J]. Am J Clin Nutr, 1976, 29:1127–1133. [44] Lonnerdal B, Woodhouse L R, Glazier C.Compartmentali- zation and quantitation of protein in human milk[J]. J Nutr, 1987, 117:1385–1395. [45] McCrory MA, Nommsen-Rivers LA, Mole PA,et al. Randomized trial of the short-term effects of dieting compared with dieting plus aerobic exercise on lactation performance [J]. Am J Clin Nutr, 1999, 69：959–967. [46] Morton J, Wong RJ, Hall JY,et al. Combining hand techniques with electric pumping increases the caloric content of milk in mothers of preterm infants[J]. J Perinatol, 2012, 32:791–796. [47] Motil KJ, Kertz B, Thotathuchery M.Lactational performance of adolescent mothers shows preliminary differences from that of adult women[J]. J Adolesc Health, 1997, 20:442–449. [48] Qian JH, Chen TX, Lu WM,et al. Breast milk macro- and micronutrient composition in lactating mothers from suburban and urban Shanghai[J]. J Paediatr Child Health, 2010, 46:115–120. [49] Rakicioğlu N, Samur G, Topçu A, et al. The effect of Ramadan on maternal nutrition and composition of breast milk[J]. Pediatr Int, 2006, 48:278–283. [50] Rana IA, Gilani M, Jafri S.Nutritive value of human milk and nutritional status of wives of army personnel of low income from Rawalpindi[J]. J Pak Med Assoc, 1990, 40:109–112. [51] Saarela T, Kokkonen J, Koivisto M.Macronutrient and energy contents of human milk fractions during the first six months of lactation[J]. Acta Paediatr, 2005, 94:1176–1181. [52] Salah ET,Malik NME,Hassan MS,et al. How does the fasting of ramadan affect breast milk constituents?[J]. Sudan J Med Sci, 2016, 11:17–22. [53] Sanchez-Hidalgo VM, Flores-Huerta S, Matute G, et al. Whey protein/casein ratio and nonprotein nitrogen in preterm human milk during the first 10 days postpartum[J]. J Pediatr Gastroenterol Nutr, 1998, 26:64–69. [54] Sanchez-Pozo A,Lopez J,Pita ML,et al. Changes in the protein fractions of human milk during lactation[J]. Ann Nutr Metab, 1986, 30:15–20. [55] Sarwar G, Darling P, Ujiie M,et al. Use of amino acid profiles of preterm and term human milks in evaluating scoring patterns for routine protein quality assessment of infant formulas[J]. J AOAC Int, 1996, 79:498–502. [56] Sauer CW, Boutin MA, Kim JH.Wide variability in caloric density of expressed human milk can lead to major underestimation or overestimation of nutrient content[J]. J Hum Lact, 2017, 33:341–350. [57] Schanler RJ, Oh W.Composition of breast milk obtained from mothers of premature infants as compared to breast milk obtained from donors[J]. J Pediatr, 1980, 96:679–681. [58] Shehadeh N, Aslih N, Shihab S,et al. Human milk beyond one year post-partum: lower content of protein, calcium, and saturated very long-chain fatty acids[J]. J Pediatr, 2006, 148:122–124. [59] Svanberg U, Gebre-Medhin M, Ljungqvist B,et al. Breast milk composition in Ethiopian and Swedish mothers. III. Amino acids and other nitrogenous substances[J]. Am J Clin Nutr, 1977, 30:499–507. [60] Thomas MR, Chan GM, Book LS.Comparison of macronu- trient concentration of preterm human milk between two milk expression techniques and two techniques for quantitation of energy[J]. J Pediatr Gastroenterol Nutr, 1986, 5:597–601. [61] Underwood BA, Hepner R,Abdullah H.Protein, lipid, and fatty acids of human milk from Pakistani women during prolonged periods of lactation[J]. Am J Clin Nutr, 1970, 23:400–407. [62] van Steenbergen WM, Kusin JA, de With C,et al. Lactation performance of mothers with contrasting nutritional status in rural Kenya [J]. Acta Paediatr Scand, 1983, 72：805–810. [63] Steenbergen W, Kusin J, Rens M.Lactation performance of Akamba mothers,Kenya. Breast feeding behaviour, breast milk yield and composition[J]. J Trop Pediatr, 1981, 27:155–161. [64] Villalpando S,Butte NF, Flores-Huerta S,et al. Qualitative analysis of human milk produced by women consuming a maize-predominant diet typical of rural Mexic[J]. Ann Nutr Metab, 1998, 42:23–32. [65] Walker ARP,Arvidsson UB,Draper WL.The composition of breast milk of South African Bantu mothers[J]. Trans R Soc Trop Med Hyg, 1954, 48:395–399. [66] Yamawaki N, Yamada M, Kan-no T,et al. Macronu- trient, mineral and trace element composition of breast milk from Japanese women[J]. J Trace Elem Med Biol, 2005, 19:171–181. [67] Zavaleta N,Lanata C, Butron B, et al. Effect of acute maternal infection on quantity and composition of breast milk[J]. Am J Clin Nutr, 1995, 62:559–563. [68] 常莹,白继国,戴建华,等. 北京郊区1-6月乳儿食乳量及母乳成分的测定[J]. 生理科学,1984,4:40. [69] 戴定威,唐译嫒. 早产儿母乳主要成分的矿质物动态分析[J]. 华西医科大学学报,1991,22:332–336. [70] 江蕙芸,陈红慧,杨万清,等. 广西三江侗族乳母膳食营养与乳汁成分的调查分析[J]. 南方医科大学学报, 2009, 29: 1474–1476. [71] 李再荣,温丽娟,张翠玉,等. 营养膳食护理对围生育期哺乳妇女乳汁的影响[J]. 黑龙江医药科学, 2015, 38:92–94. [72] 米延,张馨丹. 哈尔滨地区早产儿母乳营养素含量的调查研究[J]. 中国新生儿科杂志, 2007,22:337–339. [73] 钱继红,吴圣楣,张伟利,等. 上海地区母乳成分调查[J]. 上海医学,2002,25:396–398. [74] 王文广,殷太安,李丽祥,等. 北京市城乡乳母的营养状况、乳成分、乳量及婴儿生长发育关系的研究 Ⅰ.乳母营养状况、乳量及乳中营养素含量的调查[J]. 营养学报, 1987,9:338–342. [75] 魏九玲,任向楠,王鑫,等. 中国六地区人乳宏量营养成分研究[J]. 营养学报, 2020, 42:7–11. [76] 吴立芳. 母乳重要成分研究及其结果与婴幼儿配方粉对比研究 [D]. 北京:中国疾病预防控制中心, 2015. [77] 张志国,孙亚范,田玉新,等. 唐山地区母乳中营养成分分析[J]. 食品研究与开发,2018,39:175–179. [78] 赵江,万蓉,刘志涛,等. 2011-2012年云南省汉族、白族和傣族母乳成分及影响因素[J].卫生研究,2017, 46:573–578. [79] 赵文鼎,庞文贞. 乳母营养对乳汁质量的影响[J]. 营养学报, 1984,6:47–57. [80] 赵熙和,徐志云,王燕芳,等. 北京市城乡乳母营养状况、乳成分、乳量、及婴儿生长发育关系的研究 Ⅳ.母乳中蛋白质及氨基酸含量[J]. 营养学报,1989,11:227–232. [81] 赵勇济,孟庆兰,李贞爱,等. 不同分娩方式对乳汁成分和生后一个月婴儿生长发育影响的探讨[J]. 生理科学, 1987,7:100–104. [82] 周小兰,荆亚茹,张永爱,等. 产妇心理状态对母乳质量的影响[J]. 陕西医学杂志, 2007, 36:889–890. [83] 周韫珍,苏宜香,林敏,等. 乳母营养与乳汁成分分析[J]. 营养学报,1987,9:227–233. [84] Lönnerdal B,Erdmann P, Thakkar SK,et al. Longitudinal evolution of true protein, amino acids and bioactive proteins in breast milk:a developmental perspective[J]. J Nutr Biochem, 2017, 41L:1–11. [85] Liao YL,Weber D, Xu W,et al. Absolute quantification of human milk caseins and the whey/casein ratio during the first year of lactation[J]. J Proteome Res, 2017, 16:4113–4121. [86] Nommsen LA, Lovelady CA, Heinig MJ,et al. Deter- minants of energy, protein, lipid, and lactose concen- trations in human milk during the first 12 mo of lactation:the DARLING Study[J]. Am J Clin Nutr, 1991, 53:457–465. [87] Gidrewicz DA, Fenton TR.A systematic review and meta-analysis of the nutrient content of preterm and term breast milk[J]. BMC Pediatr, 2014, 14:216. [88] Zhang ZY, Adelman AS, Rai D,et al. Amino acid profiles in term and preterm human milk through lactation: a systematic review[J]. Nutrients, 2013, 5: 4800–4821. [89] Lemons JA, Reyman D, Moye L.Amino acid composition of preterm and term breast milk during early lactation[J]. Early Hum Dev, 1983, 8:323–329. [90] Harzer G, Franzke V,Bindels JG.Human milk nonprotein nitrogen components: changing patterns of free amino acids and urea in the course of early lactation[J]. Am J Clin Nutr, 1984, 40:303–309. [91] Velona T, Abbiati L, Beretta B,et al. Protein pro- files in breast milk from mothers delivering term and preterm babies[J]. Pediatr Res, 1999, 45:658–663.
