目的 研究巴西绿蜂胶对老年人血糖、血脂,以及血清蛋白、抗体和细胞因子水平的影响。方法 从天津某社区招募老年人,签订知情同意书。受试者每日摄入4粒蜂胶软胶囊,分两次饭后服用,每次2粒,每粒0.5 g,共服用12 w。在基线、6、12 w时分别采肘静脉血,离心取血清后,采用试剂盒检测空腹血糖、血脂、血清蛋白、抗体（IgA、IgG、IgM）和细胞因子（IL-4、IL-1β、INF-γ）水平。采用24 h膳食回顾法进行膳食调查。结果 实验结束时,受试者的空腹血糖水平显著低于基线和6 w时的水平（P<0.05）; 6 w时受试者的血清IgG水平显著高于基线水平（P<0.05）,12 w时显著低于6 w水平（P<0.05）,但与基线无显著性差异;6、12 w时血清IgA水平显著低于基线水平（P<0.05）。巴西绿蜂胶对老年人血脂、血清蛋白、IgM和细胞因子的影响不明显。两次膳食调查的结果表明,受试者能量和营养素的摄入量无显著性变化。结论 巴西绿蜂胶可降低老年人血糖和IgA水平、影响IgG水平。
Abstract
Objective To investigated effects of Brazilian green propolis on serum glucose, lipids, proteins, antibodies and inflammatory factors in the elderly. Methods A total of thirty-two residents aged over 60 years were recruited from a community of Tianjin. They signed informed consent and took 4 propolis soft capsules (0.5g per capsule) daily. The capsules were taken after meal, 2 capsules per time and two times per day. The intervention time lasted for 12 weeks. Elbow venous blood was collected at baseline, 6w and 12w, respectively. The levels of fasting serum glucose, proteins, lipids, antibodies (IgA, IgG and IgM) and cytokines (Il-4, Il-1β and INF-γ) were detected by commercial kits. Dietary survey was conducted using a 24-hour dietary recall method. Results At the end of experiment, the fasting serum glucose level was significantly lower than that at baseline or 6 weeks (P<0.05). The serum IgG level at 6 w was significantly higher than that at baseline, and the 12 w level was notably lower than the 6w level (P<0.05). There was no significant difference between 12w and baseline in the serum IgG level (P<0.05). The serum IgA levels at 6 w and 12 w were remarkably lower than the level at baseline (P<0.05). Brazilian green propolis had little effect on serum lipid, proteins, IgM and cytokines in aged people. The results of the two dietary surveys showed no significant difference in the intake of energy and nutrients. Conclusion Brazilian green propolis can lower the levels of serum glucose and IgA, and may affect the level of serum IgG.
关键词
蜂胶 /
血糖 /
血脂 /
抗体 /
细胞因子 /
老年人
Key words
Brazilian green propolis /
blood glucose /
serum lipids /
antibody /
cytokines /
the elderly
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