目的 分析孕期膳食叶酸及相关维生素摄入对新生儿脐带血叶酸代谢水平的影响。方法 基于“母子营养与健康队列”,纳入北京、山东妇幼保健机构妊娠23~29 w孕妇作为研究对象,采用3 d 24 h膳食回顾进行孕期膳食调查,计算膳食叶酸、维生素B6、维生素B12的摄入量,随访至分娩,采集新生儿脐带血,检测红细胞叶酸、血清叶酸和总同型半胱氨酸（total homocysteine, tHcy）水平。结果 共139对孕妇和新生儿纳入本研究,新生儿脐带血红细胞叶酸、血清叶酸和同型半胱氨酸中位数分别为925.86（P25~P75: 854.77~1040.09）ng/ml、49.60（P25~P75: 37.57~53.48）nmol/L和 5.32（P25~P75: 3.67~6.47）μmol/L。母亲膳食叶酸摄入不足者其新生儿脐带血红细胞叶酸、血清叶酸水平较低,而tHcy水平较高,但差异无统计学意义（P>0.05）;母亲膳食维生素B6摄入不足者其新生儿脐带血tHcy水平较高,但差异无统计学意义[P50(P25~P75)：5.38(3.74~6.62)vs4.23(2.75~6.15), P=0.063]。多元线性回归分析显示脐带血红细胞叶酸、血清叶酸和tHcy水平与孕期膳食相关维生素摄入无明显关联（P>0.05）。结论 孕期膳食叶酸及相关维生素摄入与新生儿脐带血叶酸代谢水平无明显关联,有待进一步研究。
Abstract
Objective To analyze the effects of dietary folate and related vitamins intake during pregnancy on neonates folate metabolism levels. Methods Pregnant women（23 to 29 weeks of gestation）were recruited from maternal and child health care hospital of Beijing and Shandong from the "Mother&Child Nutrition and Health Cohort". A dietary survey was conducted using a 3-day 24-hour dietary recall to calculate the intakes of the dietary folate, vitamin B6 and vitamin B12. After follow-up to delivery, neonatal cord blood was collected and the levels of red blood cell folate, serum folate, and total homocysteine were detected. Results A total of 139 pairs of pregnant women and neonates were included in the study. The median values of neonatal umbilical cord blood erythrocyte folate, serum folate and homocysteine were 925.86 (P25-P75: 854.77-1040.09) ng/ml, 49.60 (P25-P75: 37.57-53.48) nmol/L and 5.32 (P25-P75: 3.67-6.47) μ mol/L, respectively. The maternal dietary folate intake was insufficient, and neonatal umbilical cord blood erythrocyte folate and serum folate levels were lower, while the tHcy levels were higher. However, there is no significant difference (P>0.05). The neonatal umbilical cord blood tHcy level was higher in mother with insufficient dietary vitamin B6 intake, but there was no significant difference [P50 (P25-P 75): 5.38 (3.74-6.62) vs 4.23 (2.75-6.15), P=0.063]. Multiple linear regression analysis showed that the levels of folate in umbilical cord blood erythrocytes, serum folic acid and tHcy were not significantly correlated with the intake of dietary related vitamins during pregnancy (P>0.05). Conclusion The intakes of dietary folate and related vitamins during pregnancy were not significantly correlated with folic acid metabolism levels in neonatal umbilical cord blood, which needs further study.
关键词
孕期 /
膳食 /
叶酸 /
新生儿脐带血 /
同型半胱氨酸
Key words
pregnancy /
diet /
folate /
newborn umbilical cord blood /
homocysteine
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