目的 探索儿童青少年血清维生素D(VD)水平与血脂异常的关联。方法 采用多阶段分层随机整群抽样方法选取1873名6~18岁儿童青少年,进行问卷调查、体格检查、血脂代谢指标及血清25羟维生素D[25(OH)D]水平检测,采用非条件Logistic回归分析25(OH)D水平与血脂异常关联。结果 血清VD水平与TC、LDL-C浓度呈正相关,与TG负相关（rTC=0.167,rTG=-0.139,rLDL-C=0.144;均P<0.001）;将VD水平按四分位数分组,调整了性别、年龄、地区、睡眠、中高强度体力活动,每日户外活动、营养素补充剂摄入等因素后,Logistic回归分析结果显示,与VD水平处于第四分位数者相比,VD水平处于第一分位数者TC、LDL-C异常风险显著降低（ORTC=0.306;95%CI: 0.171~0.549;ORLDL-C=0.287;95%CI: 0.151~0.545）,VD水平处于第三分位数者TG异常风险显著升高（ORTG=1.764;95%CI: 1.183~2.632）。结论 血清VD对不同血脂成分影响不同,低水平VD与TC、LDL-C异常风险较低相关,与TG异常风险较高相关。
Abstract
Objective To investigate the correlation between serum vitamin D (VD) levels and dyslipidemia in children and adolescents. Methods A total of 1873 children and adolescents aged 6 to 18 years were selected through multi-stage stratified random cluster sampling. Questionnaire surveys and physical examination were performed. Lipid profiles and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The association between 25(OH)D levels and dyslipidemia was analyzed using unconditional Logistic regression. Results Serum VD levels were positively correlated with TC and LDL-C concentrations and negatively correlated with TG levels (rTC=0.167, rTG=–0.139, rLDL-C=0.144; All P<0.001). After adjusted for gender, age, region, sleep, moderate-to-high-intensity physical activity, daily outdoor activities, and nutrient supplement intake, logistic regression analysis indicated that those in the lowest quartile (first quartile) had a significantly lower risk of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) abnormalities compared with individuals in the highest quartile of VD levels (fourth quartile) (ORTC=0.306;95%CI: 0.171-0.549;ORLDL-C=0.287;95%CI: 0.151-0.545). In contrast, individuals in the third quartile of VD levels exhibited a higher risk of triglyceride (TG) abnormalities compared with individuals in the highest quartile of VD levels (fourth quartile) (ORTG=1.764;95%CI: 1.183~2.632). Conclusion Serum VD has different effects on different lipid components. Lower VD levels are associated with a reduced risk of TC and LDL-C abnormalities but an increased risk of TG abnormalities.
关键词
维生素D /
血脂异常 /
儿童青少年
Key words
vitamin D /
dyslipidemia /
children and adolescents
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