上海市成熟母乳中主要类胡萝卜素水平与婴幼儿过敏反应的关联性分析

王靓; 王贺; 许子骐; 张乐言; 倪梦梅; 陈锦瑶

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营养学报 ›› 2025, Vol. 47 ›› Issue (5) : 431-438.

论著

上海市成熟母乳中主要类胡萝卜素水平与婴幼儿过敏反应的关联性分析

王靓, 王贺, 许子骐, 张乐言, 倪梦梅, 陈锦瑶

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CORRELATION ANALYSIS OF MAJOR CAROTENOID LEVELS IN MATURE BREAST MILK AND ALLERGIC REACTIONS IN INFANTS IN SHANGHAI

WANG Liang, WANG He, XU Zi-qi, ZHANG Le-yan, NI Meng-mei, CHEN Jin-yao

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摘要

目的探讨上海市乳母哺乳中后期成熟母乳中主要类胡萝卜素（叶黄素、玉米黄质、β-隐黄质、β-胡萝卜素和番茄红素）水平与婴幼儿过敏反应的关联,为婴幼儿过敏反应的防控提供科学的理论和策略依据。方法纳入2018年1月-2019年8月从上海交通大学医学院附属新华医院妇产科门诊招募的健康单胎足月分娩的哺乳期女性及其新生儿;采集产后200~400 d的成熟母乳样本,同时收集婴儿从出生到采集母乳当天的过敏情况;高效液相色谱法检测母乳中类胡萝卜素含量;Mann-Whitney U检验和Logistic回归法分析母乳中类胡萝卜素水平与婴幼儿过敏反应的关联性及影响因素。结果共纳入200对母婴;叶黄素是所分析的母乳中含量最高的类胡萝卜素;70名婴幼儿报告有过敏史。Mann-Whitney U检验结果显示,具有过敏症状的婴幼儿与无过敏症状的婴幼儿相比,母乳中叶黄素和玉米黄质的含量存在显著差异（P<0.05）;Logistic回归分析进一步表明,随着成熟母乳中叶黄素含量的逐渐升高,婴儿出现过敏症状的风险逐渐降低（OR=0.843, 95%CI: 0.714~0.996）,而其他类胡萝卜素水平与过敏风险无显著关联。结论母乳中叶黄素的水平对婴幼儿过敏反应具有积极的影响,婴幼儿早期生命发育过程中关注叶黄素的摄入水平可能具有重要的临床意义。

Abstract

Objective To explore the association between the levels of major carotenoids (lutein, zeaxanthin, β-cryptoxanthin, β-carotene, and lycopene) in mature breast milk of postpartum women in Shanghai and the allergic reactions in infants, so as to provide a scientific theoretical framework and strategic basis for the prevention and management of allergic reactions in infants. Methods Healthy singleton full-term lactating women and their newborns were recruited from the obstetrics and gynecology outpatient department of Xinhua hospital affiliated to Shanghai Jiao Tong University School of Medicine from January 2018 to August 2019. Mature breast milk samples were collected from women within 200 to 400 days postpartum. Baby's allergy status from birth to the day of breast milk collection was also investigated. High performance liquid chromatography was used to detect the contents of carotenoids in breast milks. Mann Whitney U test and logistic regression were used to analyze the association between carotenoid levels in breast milks and allergic reactions in infants. Results A total of 200 pairs of maternal and infant data were included. Lutein was the most abundant carotenoid in the analyzed breast milks. Among them, 70 infants and young children reported a history of allergies. The Mann Whitney U test indicated that there was a significant difference (P<0.05) in the contents of lutein and zeaxanthin in breast milks between infants with allergic symptoms and those without allergic symptoms. Logistic regression analysis further showed that as the lutein content in mature breast milks gradually increased, the risk of allergic symptoms in infants gradually decreased (OR=0.843, 95% CI: 0.714-0.996),while other carotenoid levels were not significantly associated with allergic risk. Conclusion The level of lutein in breast milk has a positive impact on allergic reactions in infants. Therefore, the intake level of lutein during early life development in infants may have important clinical significance.

导出引用

王靓, 王贺, 许子骐, 张乐言, 倪梦梅, 陈锦瑶. 上海市成熟母乳中主要类胡萝卜素水平与婴幼儿过敏反应的关联性分析[J]. 营养学报. 2025, 47(5): 431-438

WANG Liang, WANG He, XU Zi-qi, ZHANG Le-yan, NI Meng-mei, CHEN Jin-yao. CORRELATION ANALYSIS OF MAJOR CAROTENOID LEVELS IN MATURE BREAST MILK AND ALLERGIC REACTIONS IN INFANTS IN SHANGHAI[J]. Acta Nutrimenta Sinica. 2025, 47(5): 431-438

中图分类号： R153.1

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