EFFECTS OF YEAST PROBIOTICS ON GUT MICROBIOTA AND SYMPTOM IN CHILDREN WITH ALLERGIC RHINITIS
JIN Zhe-yu, ZHANG Hua-qi, YANG Chuang, ZHU Ya, LIU Jin, YANG Nian-hong
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Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China
Objective To explore the characteristics of gut microbiota in children with allergic rhinitis (AR) and to evaluate the effects of yeast probiotics intervention on gut microbiota composition and the improvement of allergy symptoms. Methods Twenty children aged 6-8 years with AR were included in the intervention group, and seven healthy children were included as the control group. Standardized questionnaires were used to assess nasal and gastrointestinal symptoms, and fecal samples were collected for microbiota analysis. Children with AR received yeast probiotics (Angel brand) once daily for 8 weeks. Nasal and gastrointestinal symptoms were reassessed at 4 weeks and 8 weeks follow-up, and fecal samples were collected at week 8 again. Fecal DNA was extracted and analyzed using 16S rRNA gene sequencing to characterize the gut microbiota. The gut microbiota profiles of children with allergic rhinitis (AR) were compared with those of the healthy control group. Children with AR were further divided into mild and severe subgroups based on baseline nasal symptom scores, and changes in gut microbiota characteristics after intervention, as well as their association with symptom scores, were analyzed. Results Compared with the control group, the AR group exhibited significantly lower abundances of Actinobacteria, Bifidobacterium, and Streptococcus thermophilus (P<0.05). After 4 or 8 weeks of intervention, both nasal symptom scores and gastrointestinal symptom score decreased significantly in the severe AR subgroup, along with significant increase in Bifidobacterium, Lactobacillus, Bifidobacterium longum. Conclusion This study demonstrates that yeast probiotics supplementation effectively modifies gut microbiota composition and alleviates both nasal and gastrointestinal symptoms in children with severe symptoms.
JIN Zhe-yu, ZHANG Hua-qi, YANG Chuang, ZHU Ya, LIU Jin, YANG Nian-hong.
EFFECTS OF YEAST PROBIOTICS ON GUT MICROBIOTA AND SYMPTOM IN CHILDREN WITH ALLERGIC RHINITIS[J]. Acta Nutrimenta Sinica. 2026, 48(2): 118-127
中图分类号：
R153.2
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