高原高尿酸血症的发病机制与营养干预的研究进展

吕飞; 白晨; 张予弦; 孙铁强; 侯丽雪; 虞立霞

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营养学报 ›› 2026, Vol. 48 ›› Issue (2) : 193-199.

综述

高原高尿酸血症的发病机制与营养干预的研究进展

吕飞¹, 白晨⁴, 张予弦², 孙铁强², 侯丽雪³, 虞立霞²

作者信息 +

PROGRESS ON THE PATHOGENESIS OF PLATEAU HYPERURICEMIA AND NUTRITIONAL INTERVENTION

LV Fei¹, BAI Chen⁴, ZHANG Yu-xian², SUN Tie-qiang², HOU Li-xue³, YU Li-xia²

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文章历史 +

摘要

高原环境极易引起机体代谢紊乱,高尿酸血症是高原地区常见的代谢紊乱综合征,主要涉及内源性尿酸合成增加、排泄障碍以及炎症和氧化应激、肠道功能紊乱等。由于目前的治疗药物存在诸多禁忌症和不良反应,安全有效的营养干预措施亟待研究和开发。大量研究表明,营养素、天然活性成分及植物提取物等在干预高尿酸血症方面具有潜在优势。本文概述了高原高尿酸血症的发病机制及其营养干预策略,旨在为高原高尿酸血症营养防治提供参考。

Abstract

The plateau environments are extremely prone to inducing metabolic disorders. Hyperuricemia, a common metabolic disorder syndrome in plateaus, is primarily associated with increased endogenous uric acid synthesis, impaired uric acid excretion, inflammation and oxidative stress, and intestinal dysfunction. Due to the numerous contra-indications and side effects of current therapeutic drugs, there is an urgent need to develop safe and effective nutritional interventions. Numerous studies have indicated that the supplementation with some nutrients, natural active ingredients and plant extracts holds potential advantages in the intervention of hyperuricemia. This review provides an overview on the pathogenesis of plateau-associated hyperuricemia and its potential nutritional intervention strategies, so as to provide references for the development of effective nutritional intervention against hyperuricemia in plateaus.

导出引用

吕飞, 白晨, 张予弦, 孙铁强, 侯丽雪, 虞立霞. 高原高尿酸血症的发病机制与营养干预的研究进展[J]. 营养学报. 2026, 48(2): 193-199

LV Fei, BAI Chen, ZHANG Yu-xian, SUN Tie-qiang, HOU Li-xue, YU Li-xia. PROGRESS ON THE PATHOGENESIS OF PLATEAU HYPERURICEMIA AND NUTRITIONAL INTERVENTION[J]. Acta Nutrimenta Sinica. 2026, 48(2): 193-199

中图分类号： R151

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