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CJAP ›› 2018, Vol. 34 ›› Issue (6): 550-554.doi: 10.12047/j.cjap.5698.2018.123

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Effects of Radix Hedysari, Radix Astragalus and compatibility of Angelica Sinensis on blood deficiency model mice induced by cyclophosphamide

YANG Xiu-juan1,2, YANG Zhi-jun1,2, LI Shuo1,2, JI Xiu-jia1, Ning Yan-mei1, WANG Yan1   

  1. 1. Gansu University of Chinese Medicine, Lanzhou 730000, China;
    2. Key Laboratory of Chemistry and Quality for Chinese Medicine of Gansu Province, Lanzhou 730000, China
  • Received:2018-04-18 Revised:2018-10-26 Online:2018-11-28 Published:2019-03-09
  • Supported by:
    甘肃省教育厅高等学校科研项目(2016B-055,2017A-056),甘肃省中医药管理局(GZK-2017-7),敦煌医学与转化教育部重点实验室开放基金项目(DHYX18-11)

Abstract: Objective: To study the intervention effects of Radix Hedysari, Radix Astragalus and compatibility of Angelica Sinensis on blood deficiency model mice induced by cyclophosphamide (CTX). Methods: The mice were randomly divided into 7 groups, 10 mice each group. The blood deficiency model was established by CTX. The blank group and model group were treated with saline by gavage, while mice in positive group were administered with Lvjiaobuxue granule. Four dosage group were administered with Radix Hedysari, Radix Hedysari-Radix Angelica Sinensis(5:1), Radix Astragalus and Radix Astragalus-Radix Angelica Sinensis(5:1) water decoction. All the drugs were administered to mice for consecutive 7 d. The contents of red blood cell (RBC), lymphocyte(LYM), hematocrit (HCT), white blood cell (WBC), platelet (PLT) were detected by hematology analyzer, while thymus index(TI), spleen index(SI), reticulocyte (RC), marrow karyocyte (MK) were calculated, and the femur by pathological section were observed by microscope. Results: Compared with blank group, the contents of RBC, WBC, HCT, PLT, LYM were decreased in model group (P<0.05). Compared with model group, the contents of RBC, WBC, HCT, PLT, LYM, RC and marrow karyocyte were increased in Hedysari-Angelica Sinensis(5:1) and Astragalus Angelica Sinensis(5:1) (P<0.05), at the same time, the pathological damage of femur could be improved. Conclusion: The effect of enrichment blood on blood deficiency model mice in Hedysari-Angelica Sinensis (5:1) and Astragalus-Angelica Sinensis(5:1) were superior to Hedysari and Astragalus.

Key words: Radix Hedysari, Astragalus, Angelica, cyclophosphamide, blood deficiency, mice

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