Human experiments of metabolism, blood alkalization and oxygen effect on control and regulation of breathing II: room air exercise test after blood alkalization

doi:10.12047/j.cjap.0117.2015.012

Abstract

Abstract: Objective: Basis on the dynamic changes of the ventilation and arterial blood gas parameters to symptom-limited maximum cardiopulmonary exercise testing (CPET),we further investigate the effect of alkalized blood by drinking 5% NaHCO₃ on ventilation during exercise. Methods: After drinking 5% NaHCO₃75 ml (3.75 g) every 5 min, total dosage of 0.3 g/Kg, 5 volunteers repeated CPET. All CPET and ABG data changes were analyzed and calculated. At the same time, CPET and ABG parameters after alkalized blood were compared with those before alkalized blood (control) used paired t test. Results: After alkalized blood, CPET response patterns of parameters of ventilation, gas exchange and arterial blood gas were very similar (P>0.05). All minute ventilation, tidal volume, respiratory rate, oxygen uptake and carbon dioxide elimination were gradually increased from resting stage (P<0.05~0.001), according to the increase of power loading. During CPET after alkalized blood,ABG parameters were compared with those of control: hemoglobin concentrations were lower,CaCO₂and pHa were increased at all stages（P<0.05）. The PaCO₂ increased trend was clear, however only significantly at warm-up from 42 to 45 mmHg （P<0.05）. Compared with those of control, only the minute ventilation was decreased from 13 to 11 L/min at resting (P<0.05). Conclusion: Even with higher mean CaCO₂, PaCO₂ and pHa, lower Hba and [H⁺]a, the CPET response patterns of ventilatory parameters after alkalized blood were similar.

Key words: blood alkalization, cardiopulmonary exercise testing, respiratory response pattern, room air, respiratory frequency, tidal volume, minute ventilation

CLC Number:

R332.3

SUN Xing-guo, STRINGER WW, YIN Xi, GE Wan-gang, WANG Gui-zhi, LV Jing, LIU Fang, CI Zheng, WASSERMAN K. Human experiments of metabolism, blood alkalization and oxygen effect on control and regulation of breathing II: room air exercise test after blood alkalization[J]. CJAP, 2015, 31(4): 345-351.

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