Home  About Journal Instructions for Authors Editorial Board Subscribe Advertisement Messages Board Contact Us 中文

CJAP ›› 2018, Vol. 34 ›› Issue (6): 530-535.doi: 10.12047/j.cjap.5755.2018.118

Previous Articles     Next Articles

Prognosis-related miRNA bioinformatics screening of lung adenocarcinoma and its clinical significance

ZHANG Hao-min1,2, YANG Bo2, CHEN Hong-fei2, CHI Xiao-hua3, XI Yi-bo1,2, CHEN Xi-meng1,2, GUO Bin1,2, HE Pei-feng1, LU Xue-chun2   

  1. 1. Management School Shanxi Medical University, TaiYuan 030002;
    2. Department of Hematology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853;
    3. Department of Pharmacy, Chinese PLA Rocket Force General Hospital, Beijing 100800, China
  • Received:2018-09-25 Revised:2018-10-26 Online:2018-11-28 Published:2019-03-09
  • Supported by:
    2017年度国家老年疾病临床医学研究中心招标课题(NCRCG-PLAGH-2017011);解放军总医院转化医学项目(2017TM-020)

Abstract: Objective: To investigate the prognosis-related miRNA histological features and clinical significance of lung adenocarcinoma. Methods: Using The Cancer Genome Atlas (TCGA) data, the miRNA expression profile data of human lung adenocarcinoma were searched for differential analysis, and the prognosis-related miRNAs were screened by Cox risk regression model. The targeted miRNAs were predicted by mirwalk analysis platform, KEGG functional enrichment analysis, and finally, predict the function of prognosis-related miRNAs. Results: A total of 46 differential miRNAs in lung adenocarcinoma were screened, including 19 up-regulated and 27 down-regulated. Six prognostic-related miRNAs were screened by Cox survival analysis, namely hsa-mir-21, hsa-mir-142, hsa-mir-200a high expression, hsa-mir-101, hsa-let-7c, hsa-mir-378e low expression, hsa-mir-21 and hsa-mir-378e were associated with poor prognosis in patients with lung adenocarcinoma, and the survival time was shortened significantly (P<0.05, AUC=0.618). KEGG analysis showed that the above prognosis-related miRNA targeting regulatory genes were related with immune response pathways, miRNA and cancer pathways, metabolic pathways and so on. Conclusion: Hsa-mir-21 and hsa-mir-378e are associated with poor prognosis of lung adenocarcinoma, and may be used as a molecular marker for prognosis of lung adenocarcinoma after further clinical verification.

Key words: lung adenocarcinoma, miRNA, TCGA, prognosis, bioinformatics

Copyright © 2015 CJAP, All Rights Reserved.
Powered by Beijing Magtech Co. Ltd