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CJAP ›› 2018, Vol. 34 ›› Issue (2): 154-158.doi: 10.12047/j.cjap.5542.2018.038

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The influence of benazepril and amlodipine on the expression of secretin and somatostatin in spontaneously hypertensive rats

JIN Hua1,2, LIU Zhi-jun1, YAN Chun-lu1, LIU Feng-lin1, CHEN Li1, ZHANG Qiu-ju1, XU Hou-qian1, HU Ji-hong1, DOU Rong-hai1, WEN Xin-yang1   

  1. 1. Gansu University of Chinese Medicine, Lanzhou 730000;
    2. Laboratory of Herbs Mining and Innovation and Transformation of Traditional Chinese Medicine in Gansu Province, Lanzhou 730000, China
  • Received:2016-12-20 Revised:2017-10-27 Online:2018-03-28 Published:2018-05-22
  • Supported by:
    国家自然科学基金资助项目(81160477);甘肃省自然科学研究基金计划(1107RJZA220);甘肃省高等学校科研项目协同创新团队项目(2017C-14)

Abstract: Objective:Investigate the influence of benazepril and amlodipine on the expression of secretin (PZ) and somatostatin (SS) in spontaneously hypertensive rats (SHR). Methods:Forty-five SHRs (14 weeks old, male) were randomly assigned into 3 groups (n=15):SHR group, Benazepril group (which was given benazepril 0.90 mg·kg-1·d-1) and Amlodipine group (SHRs were given amlodipine 0.45 mg· kg-1·d-1), taking WistarKyoto(WKY) as normal control (n=15), meanwhile, rats in SHR group and WKY group were given the same volume of distilled water. After 8 weeks of intervention, the expression of protein and mRNA of PZ in duodenum and SS in sinuses ventriculi was detected by enzyme-linked immunoassay and RT-PCR. Results:After 8 weeks of intervention, compared with the WKY group, the expression of protein and mRNA of PZ in duodenum and SS in sinuses ventriculi was increased significantly in SHR group (P<0. 05). Compared with SHR group, the expression of PZ in duodenum and SS in sinuses ventriculi was decreased significantly in Benazepril group and Amlodipine group (P<0.05). Compared with Benazepril group, in Amlodipine group the expression of PZ mRNA in duodenum and SS mRNA in sinuses ventriculi was decreased more significantly (P<0.05). Conclusion:The regulation disorder of PZ in duodenum and SS in sinuses ventriculi exists in SHR. The antihypertensive effect of benazepril and amlodipine may be realized by regulating the expression of PZ and SS, while the regulation of amlodipine is more obvious than benazepril.

Key words: SHR, PZ, SS, benazepril, amlodipine

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