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CJAP ›› 2017, Vol. 33 ›› Issue (6): 550-554.doi: 10.12047/j.cjap.5601.2017.130

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Therapeutic effects of Chai Qin Cheng Qi decoction on severe acute pancreatitis complicated liver damage in rats and its mechanisms

DANG Lin1, ZHANG Xiao-qin1, LIU Fang1, XU Xiao-fan2, LI Fang-fang2, WEI Xu1, ZHANG Hong2   

  1. 1. School of Basic Medicine, Shanxi University of Traditional Chinese Medicine, Xianyang 712046, China;
    2. Experimental Center of Medical Science and Research, Shanxi University of Traditional Chinese Medicine, Xianyang 712046, China
  • Received:2016-09-14 Revised:2017-06-22 Online:2017-11-28 Published:2018-06-19
  • Contact: 张红,Tel:18691068302;E-mail:zhangh1227@163.com E-mail:zhangh1227@163.com
  • Supported by:
    陕西中医药大学2016年度自然科学培育基金项目(2016PY06)

Abstract: Objective: To study the effects of Chai Qin Cheng Qi Decoction(CQCQD)(Traditional Chinese Medicine)on severe acute pancreatitis (SAP)complicated liver damage in rats.Methods: Seventy-two SD rats were randomly divided into three groups(n=24):Sham group, SAP group and CQCQD treatment group. SAP model was induced by retrograde injection with sodium taurocholate. The rats in CQCQD group received treatment with CQCQD. After modeling 1 h, 5 h, 10 h, pancreas and liver histopathological changes were observed. The serum levels of interleukin-6(IL-6), amylase(AMS), alanine aminotransferase(ALT) and aspartate transaminase(AST) were detected. IL-6 and monocyte chemotactic protein 1(MCP-1)mRNA in pancreas and liver were assayed.Results: Compared with sham group, the activities of AMS,ALT and AST and the serum level of IL-6 in SAP group were increased significantly. The levels of MCP-1 and IL-6 mRNA in pancreas and liver tissue were increased (P<0.05). Compared with SAP group, the activities of AMS,ALT and AST and the level of IL-6 in CQCQD group were reduced significantly (P<0.05). The pancreas and liver tissue pathological damage alleviated. The levels of IL-6 and MCP-1mRNA in pancreas and liver were decreased significantly(P<0.05).Conclusion: MCP-1 takes part in the progression of SAP complicated liver damage; CQCQD can significantly inhibit the expression of pancreas and liver MCP-1, alleviate pathological damage of pancreas and liver in SAP and play a therapeutic role in SAP complicated liver damage.

Key words: Chai Qin Cheng Qi Decoction (CQCQD), severe acute pancreatitis (SAP), liver damage, MCP-1, rat

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