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CJAP ›› 2019, Vol. 35 ›› Issue (5): 390-392.doi: 10.12047/j.cjap.5808.2019.083

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Changes of myocardial function in diabetic rats and its mechanism

BAI Shu-zhi, XU Na, WANG Yue-hong, LI Hong-zhu, LI Hong-xia   

  1. Department of Pathophysiology, Harbin Medical University, Harbin 150086, China
  • Received:2019-01-11 Online:2019-09-28 Published:2020-01-02

Abstract: Objective: To investigate the role of calcium-sensing receptor (CaSR) in the decrease of cardiac function in type 2 diabetic rats. Methods: Wistar rats were randomly divided into 3 groups including control, diabetic-4 week and diabetic-8 week groups. Rats in the diabetes group were fed with high-glucose and high-fat diet, and intraperitoneal injection of streptozocin (STZ,30 mg/kg) was conducted 4 weeks later to establish a type 2 diabetes model. Cardiac morphological changes were observed by HE staining, cardiac function was detected by echocardiography, and CaSR and PKC-αprotein expressions in cardiac tissue were detected by Western blot. Results: Compared with the control group, the myocardium of diabetic rats showed irregular contraction zone, decreased expression of CaSR protein, increased expression of PKC-α protein, decreased systolic and diastolic functions, and gradually worsened with the prolongation of the course of the disease. Conclusion: Hyperglycemia inhibits the expression of CaSR protein in myocardium of diabetic rats by activating PKC-α, which can cause intracellular calcium disorder and lead to decreased cardiac function.

Key words: calcium-sensing receptor, type 2 diabetes, cardiac function

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