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中国应用生理学杂志 ›› 2017, Vol. 33 ›› Issue (1): 26-30.doi: 10.12047/j.cjap.5448.2017.006

• 研究论文 • 上一篇    下一篇

5-HT1A受体阻断剂对乙醇引起大鼠低体温和行为性体温调节反应的影响

杨永录, 昝旺, 卜舒, 罗蓉, 胥建辉   

  1. 成都医学院体温与炎症四川省高校重点实验室, 四川 成都 610500
  • 收稿日期:2015-09-30 修回日期:2016-06-26 出版日期:2017-01-28 发布日期:2018-06-19
  • 通讯作者: 杨永录,Tel:028-62739330,E-mail:ylyang9@sohu.com E-mail:ylyang9@sohu.com
  • 基金资助:
    四川省教育厅科研基金资助项目(12ZB204);成都医学院学科建设项目专项经费资助(CYXK2012003)

Effects of 5-HT1A receptor antagonist on ethanol induced hypothermia and behavioral thermoregulatory response in rats

YANG Yong-lu, ZAN Wang, BU Shu, LUO Rong, XU Jian-hui   

  1. Key Laboratory of Thermoregulation and Inflammation of Sichuan Higher Education Institutes, Chengdu Medical College, Chengdu 610500, China
  • Received:2015-09-30 Revised:2016-06-26 Online:2017-01-28 Published:2018-06-19
  • Supported by:
    四川省教育厅科研基金资助项目(12ZB204);成都医学院学科建设项目专项经费资助(CYXK2012003)

摘要: 目的:观察5-羟色胺1A (5-HT1A)受体阻断剂p-MPPI对乙醇引起大鼠低体温和行为性体温调节反应的影响。方法:用无线遥控测温技术记录成年雄性SD大鼠体核温度和活动的变化。用无线遥测温度梯度仪监测大鼠体核温度和行为性体温调节活动,将大鼠置于15℃~40℃的温度梯度箱内,并允许动物自由选择箱内温度,观察乙醇(3 g/kg)引起低体温和行为性体温调节的反应以及5-HT1A受体阻断剂p-MPPI (1 mg/kg)对其效应的影响。结果:①乙醇能引起大鼠快速的体温降低反应,同时动物选择较低的环境温度。②5-HT1A受体阻断剂p-MPPI能明显阻断乙醇引起的低体温和行为性体温调节变化。结论:①乙醇能使体温调定点降低,因为乙醇引起低体温时,大鼠选择较冷环境温度区;②5-HT可能参与乙醇引起低体温与行为性体温调节活动。

关键词: 乙醇, 低体温, 大鼠, 行为性体温调节, 5-HT1A受体阻断剂

Abstract: Objective: To observe the effects of 5-HT1Areceptor antagonist p-MPI on ethanol induced hypothermia and behavioral ther-moregulatory response in rats.Methods: Core temperature and motor activities were monitored in undisturbed male SD rats using radioteleme-try. The behavioral thermoregulatory response and core temperature were monitored in rats using radiotelemetric temperature gradient apparatus. The rats were placed in a temperature gradient that permitted the selection of ambient temperature ranging from 15℃ to 40℃. Effect of ethanol (3 g/kg) and 5-HT1A receptor antagonist p-MPPI(1 mg/kg) on core temperature, motor activities, and the behavioral thermoregulatory re-sponse were observed in rats.Results: ①Ethanol led to a rapid reduction in core temperature. The hypothermic responses were accompanied with a preference for cooler ambient temperature. ②5-HT1A receptor antagonist attenuated the hypothermia induced by ethanol, and accompa-nied with a selection for warmer ambient temperature.Conclusion: ①Behavioral thermoregulatory observations suggested that the ethanol could decrease the thermoregulatory set point,because rats treated with ethanol selected cooler ambient temperature facilitates the reduction in core temperature.②5-HT might be involved in ethanol-induced hypothermia and behavioral thermoregulatory response.

Key words: ethanol, hypothermia, rat, behavioral thermoregulation, 5-HT1A receptor antagonist

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