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CJAP ›› 2016, Vol. 32 ›› Issue (6): 550-554.doi: 10.13459/j.cnki.cjap.2016.06.014

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The effects of 5-HT1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus

GAO Wei1, WANG Nan2, QIAO Hu2   

  1. 1. Department of Physical Education, Xi'an University of Technology, Xi'an 710048;;
    2. Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China
  • Online:2016-11-28 Published:2018-06-19
  • Supported by:
    国家自然科学基金项目(30900544)

Abstract: Objective: To investigate the effects of the serotonergic nervous system on motor behaviors mediated by cerebellar fastigial nucleus (FN). Methods: In this experiment, the main methods are whole-cell patch clamp recording and Rota-rod test. Results: We found that the excitatory synaptic transmission was enhanced in the cerebella FN after blocking 5-hydroxytryptamine,(5-HT)receptor. Microinjection of 5-HT into FNs remarkably promoted motor performances on Rota-rod, which could be reversed by microinjection of 5-HT receptor antagonist SB224289. Conclusion: These results suggest that the 5-HT can suppress cerebellar FN excitatory synaptic transmission via 5-HT1B receptors, thereby modulate the activity of cerebellar nuclear neurons circuitry, and subsequently influence the cerebellum-mediated ongoing motor balance and coordination.

Key words: 5-HT, 5-HT1B receptor, fastigial nucleus (FN), excitatory post-synaptic currents, rat, patch clamp

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